Abstract: A system is disclosed for evaluating diagnostic effectiveness of one or more diagnostic tests or additional findings from a set of known findings as to a patient. The system includes a computing device containing a software application which is used by a healthcare provider to review the patient's medical history and enter findings as to the patient's condition or symptoms, a system storing a validated probabilistic health model including a database of medical knowledge informed from aggregated electronic medical records or other sources of medical knowledge; and a medical knowledge-based inference engine operating on the patient's medical history and findings and the validated probabilistic health model. The engine determines a set of the most probable diseases of the patient, suggests a set of one or more tests or additional findings that differentiate the set of most probable diseases, and generates indicia indicating diagnostic effectiveness or relevancy of the one or more tests or additional findings.

Abstract: A system is disclosed for evaluating diagnostic effectiveness of one or more diagnostic tests or additional findings from a set of known findings as to a patient. The system includes a computing device containing a software application which is used by a healthcare provider to review the patient's medical history and enter findings as to the patient's condition or symptoms, a system storing a validated probabilistic health model including a database of medical knowledge informed from aggregated electronic medical records or other sources of medical knowledge; and a medical knowledge-based inference engine operating on the patient's medical history and findings and the validated probabilistic health model. The engine determines a set of the most probable diseases of the patient, suggests a set of one or more tests or additional findings that differentiate the set of most probable diseases, and generates indicia indicating diagnostic effectiveness or relevancy of the one or more tests or additional findings.

Abstract: The invention provides a parathyroid hormone (PTH) compound comprising a PTH peptide. The PTH compound has a significantly increased bioavailability or circulating half-life when compared to a bioavailability or a circulating half-life of a native form of the PTH peptide. The PTH compound has a significantly greater serum concentration at multiple timepoints post-administration to a rat when compared to that of a native PTH peptide.

Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

Abstract: The invention provides non-hormonal vitamin D conjugated via the third carbon on the vitamin D backbone to parathyroid hormone (PTH) proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms.

Abstract: The invention provides a parathyroid hormone (PTH) compound comprising a PTH peptide. The PTH compound has a significantly increased bioavailability or circulating half-life when compared to a bioavailability or a circulating half-life of a native form of the PTH peptide. The PTH compound has a significantly greater serum concentration at multiple timepoints post-administration to a rat when compared to that of a native PTH peptide.

Abstract: A system is disclosed for evaluating diagnostic effectiveness of one or more diagnostic tests or additional findings from a set of known findings as to a patient. The system includes a computing device containing a software application which is used by a healthcare provider to review the patient's medical history and enter findings as to the patient's condition or symptoms, a system storing a validated probabilistic health model including a database of medical knowledge informed from aggregated electronic medical records or other sources of medical knowledge; and a medical knowledge-based inference engine operating on the patient's medical history and findings and the validated probabilistic health model. The engine determines a set of the most probable diseases of the patient, suggests a set of one or more tests or additional findings that differentiate the set of most probable diseases, and generates indicia indicating diagnostic effectiveness or relevancy of the one or more tests or additional findings.

Abstract: The invention provides non-hormonal vitamin D conjugated via the third carbon on the vitamin D backbone to parathyroid hormone (PTH) proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms.

Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.

Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.