Abstract: Examples disclosed herein provide systems, methods, and software for storing objects, such as files, via physical block addresses and media characteristics. In one example, a method for operating a processing system on a storage device includes identifying media characteristics for a storage media. The method further includes, for a given object received over a network and in association with a network storage request, identifying a plurality of physical block addresses for the given object based on the media characteristics. The method also includes initiating a transfer of the object from memory to the storage media.

Abstract: To provide enhanced operation of storage control systems associated with data storage devices, such as rotating media-based hard drives, various systems and methods are provided herein. In some examples, these systems and methods can provide for receiving write requests from a host system to write content elements to storage media in a storage subsystem. In response to the write requests, synthetic updates are generated corresponding to updates to file system information stored in the host system that are representative of the write requests. The synthetic updates are written to the storage media such that each update is stored proximately to the content elements, is non-contiguous with respect to other synthetic updates, and is removed spatially from the version of file system information stored on the storage media.

Abstract: A control system comprises an interface configured to receive a content request from a request source wherein the content request identifies content stored on a storage medium. The control system also comprises a processing system coupled to the interface and configured to process the content request to determine when the request source is a valid destination for the content based on a first identifier stored with the content. The interface is further configured to transfer the content to the request source when the request source is a valid destination.

Abstract: Modified Wee1 peptides, polynucleotides encoding those peptides, and methods for purifying the peptides and crystallizing them as peptide: inhibitor complexes have been discovered. The three-dimensional structure of Wee1, including the ATP substrate binding site, and uses of this information in the design and screening of compounds that may associate with Wee1, or peptides structurally related thereto, have also been discovered.