Abstract: The present invention relates to a method of detecting one or more tissue-derived aggregated proteins in a biological sample.

Abstract: The present invention relates to a method of detecting one or more tissue-derived aggregated proteins in a biological sample.

Abstract: Compositions, methods and systems for the treatment of a protein aggregation disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Dementia with Lewy Bodies (DLB), Huntington's disease (HD), Amylotrophic lateral sclerosis (ALS, which results from degeneration of the upper and lower motor neurones and affects the voluntary muscle system), Progressive Supranuclear Palsy (PSP), Type 2 Diabetes and Multiple systems atrophy (MSA).

Abstract: The present invention relates to a method of detecting one or more tissue-derived aggregated proteins in a biological sample.

Abstract: A method is provided for manufacturing a rotor body of a Magnus-type rotor. The method includes providing a plurality of arcuate panels, wherein each of the panels has an arc-length less than a predetermined circumference of the rotor body. The method further includes positioning at least three such arcuate panels in mutual edge-wise abutment to form circumferentially a hollow cylindrical loop, wherein longitudinal edges of adjacent panels are mutually attached to each other. The method further optionally includes co-axially stacking one above another at least two loops of substantially similar diameter. The method further includes connecting edges of adjacent loops to define the rotor body of a predetermined height.

Abstract: A method of detecting mutations in a CTC genome that uses a negative selection step to remove a proportion of non-CTCs from a blood sample. The negative selection step is followed by extraction of the DNA from the remaining enriched CTCs and then by dilution of the DNA to a very low concentration and preparing and sequencing two or more replicates of the final dilution.

Abstract: A method is provided for manufacturing a rotor body of a Magnus-type rotor. The method includes providing a plurality of arcuate panels, wherein each of the panels has an arc-length less than a predetermined circumference of the rotor body. The method further includes positioning at least three such arcuate panels in mutual edge-wise abutment to form circumferentially a hollow cylindrical loop, wherein longitudinal edges of adjacent panels are mutually attached to each other. The method further optionally includes co-axially stacking one above another at least two loops of substantially similar diameter. The method further includes connecting edges of adjacent loops to define the rotor body of a predetermined height.

Abstract: The present invention provides a method of detecting an enzyme in a sample wherein the enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule, which thereby confers altered sensitivity of the nucleic acid molecule in a subsequent process. The invention also relates to diagnostic methods which take advantage of the method of the invention and kits which are useful for carrying out the method of the invention.

Abstract: The present invention generally relates to an apparatus and method for detecting the physical condition of a tubular. In one aspect, an apparatus for use in a tubular is provided. The apparatus includes a body and a drive member for urging the apparatus through the tubular. The apparatus further includes at least two independent caliper assemblies capable of generating data representative of an interior surface of the tubular, wherein each caliper assembly includes an independent force sensor with a sensing member operatively attached thereto. In another aspect, a method for obtaining data in a tubular is provided. In yet another aspect, an apparatus for collecting data in a tubular is provided.

Abstract: Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.

Abstract: Methods and kits for detecting target molecules or for monitoring interactions between target molecules. In particular, the invention relates to methods based on the use of “two-component conjugate” systems comprising a catalytic label and a substrate label.

Abstract: A method of assay for the outcome of a reaction comprises conducting a reaction between a first reactant and a second reactant to produce from the first reactant a product having at least one new structural feature not present in the first reactant or the second reactant, e.g. by cleaving the first reactant or adding to it, producing a multiple-phage tagged complex comprising at least two different viruses and said product or said first reactant, in which complex at least one of said viruses is connected to said product using a said new structural feature or is lost from said first reactant upon formation of said new structural feature, and determining the presence or amount of said complex by a dual-phage assay.

Abstract: A method for detecting aggregation or polymerization of molecules in a sample, which method comprises the steps of: a) exposing a sample containing the molecules to at least two labelling moieties which will bind to only a single mutually exclusive site on each of the said molecules; and b) determining whether multiply-bound labelling moieties are present. The method is particularly of use in differentiating pathogenic aggregated protein molecules from non-pathogenic, non-aggregated protein molecules.