Abstract: A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.

Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.

Abstract: The present disclosure provides an expandable spinal implant comprising a plurality of moveable endplates pivotably connect to a housing.

Abstract: An expandable spinal fusion implant including first and second endplates coupled to an expansion member that sits within a housing. The expansion member is translated by a drive mechanism, whereby translation of the expansion member by the drive mechanism in a distal and proximal directions causes the distance between the endplates to increase and decrease, respectively.

Abstract: The present disclosure provides an expandable spinal implant comprising a plurality of moveable endplates pivotably connect to a housing.

Abstract: Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.

Abstract: An expandable spinal fusion implant including a housing, upper and lower endplates, a wedge positioned within the housing and between the upper and lower endplates and a drive mechanism to urge the wedge distally between the upper and lower endplates to increase the separation between the endplates and expand the overall height of the distal end of the implant.

Abstract: The invention relates to a sound protection panel for cladding a wall of an automotive vehicle, the panel includes a mass-spring system. The panel has a lower spring layer based on a resiliently compressible material, an upper mass layer based on resiliently compressible foam flakes, the flakes being bound together by a two-component fibre-based bonding agent comprising a core. The core is fusible at a high temperature or infusible, and a sheath fusible at a lower temperature, the flakes being fused with the sheath to form an upper agglomerated layer.

Abstract: An expandable spinal fusion implant including a housing, upper and lower endplates, a wedge positioned within the housing and between the upper and lower endplates and a drive mechanism to urge the wedge distally between the upper and lower endplates to increase the separation between the endplates and expand the overall height of the distal end of the implant.

Abstract: A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.

Abstract: An expandable spinal fusion implant including first and second endplates coupled to an expansion member that sits within a housing. The expansion member is translated by a drive mechanism, whereby translation of the expansion member by the drive mechanism in a distal and proximal directions causes the distance between the endplates to increase and decrease, respectively.

Abstract: A system for performing interbody fusion surgery including an expandable intervertebral spacer and specialized instruments for choosing the correct size of implant, implanting the device within the intervertebral space, and for delivery of bone graft or bone substitute to the interior of the implant.

Abstract: The present disclosure provides an expandable spinal implant comprising a plurality of moveable endplates pivotably connect to a housing.

Abstract: An expandable spinal fusion implant comprising first and second endplates coupled to an expansion member that sits within a housing. The expansion member is translated by a drive mechanism, whereby translation of the expansion member by the drive mechanism in a distal and proximal directions causes the distance between the endplates to increase and decrease, respectively.

Abstract: The invention relates to the field of analgesics. According to the invention, a kit or composition, particularly a pharmaceutical composition or a pharmaceutical kit, is provided, comprising a nanocarrier which is a hyperbranched polymer, such as a dendritic polymer or dendrimer, preferably having a molecular weight of 1,000-100,000 g/mol, and an analgesic which, when administered without nanocarrier, has both peripheral and central analgesic effect, preferably an opioid such as nalbuphine. According to the invention, the analgesic in this composition mainly or exclusively has a peripheral effect and thus reduces side effects triggered by the activation of central or intestinal opioid receptors. It is used for the treatment of peripheral pain and/or inflammation. The invention also relates to particularly suitable nanocarriers.

Abstract: The present invention relates generally to medical devices and methods for use in spinal surgery. In particular, the disclosed devices relate to a spinal fixation system and an intervertebral spinal implant assembly sized and dimensioned for the lumbar spine implantable via an anterior or anterolateral approach. The devices include an implant, bone screws, and an improved locking mechanism to prevent the back out of screws.

Abstract: An expandable spinal fusion implant including a housing, upper and lower endplates, a wedge positioned within the housing and between the upper and lower endplates and a drive mechanism to urge the wedge distally between the upper and lower endplates to increase the separation between the endplates and expand the overall height of the distal end of the implant.

Abstract: Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.

Abstract: An expandable spinal fusion implant including a housing, upper and lower endplates, a wedge positioned within the housing and between the upper and lower endplates and a drive mechanism to urge the wedge distally between the upper and lower endplates to increase the separation between the endplates and expand the overall height of the distal end of the implant.

Abstract: An expandable spinal fusion implant comprising first and second endplates coupled to an expansion member that sits within a housing. The expansion member is translated by a drive mechanism, whereby translation of the expansion member by the drive mechanism in a distal and proximal directions causes the distance between the endplates to increase and decrease, respectively.