Abstract: Provided herein are devices and methods that relate to ventilation and respiration. In one embodiment, a ventilator device comprising a fluidic amplifier with one or more coaxially aligned components, where there are no internal moving components. In another embodiment, a device and related methods for treating a patient who needs ventilation such as after infection by the coronavirus Covid-19.

Abstract: An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

Abstract: A tool holder clamp fits over the suction hose or intake nozzle of a vacuum pumper truck. The clamp takes the form of two or more C-shaped sections that can bolt together over the hose, with each C-shaped section having one or more through bores serving as sockets for holding a tool such as a flashlight or the head or nozzle of a jet hose. The sockets have associated slots to permit the socket to be snugged down against the tool.

Abstract: A tool holder clamp fits over the suction hose or intake nozzle of a vacuum pumper truck. The clamp takes the form of two or more C-shaped sections that can bolt together over the hose, with each C-shaped section having one or more through bores serving as sockets for holding a tool such as a flashlight or the head or nozzle of a jet hose. The sockets have associated slots to permit the socket to be snugged down against the tool.

Abstract: An intake nozzle fits onto the suction hose of a vacuum pumper truck. The nozzle comprises a tubular housing and the rotor within the housing near the intake end. The rotor includes a hollow cylindrical canister and spiral vanes on its exterior. Ambient air enters an air tube, penetrates the side of the housing and supplies ambient air to the interior of the canister. The air exits through outlet ports into the liquid waste as it moves past under vacuum. The injected air reduces the density of the liquid waste, speeding up the pumping process and reducing the incidence of blockages.

Abstract: An intake nozzle fits onto the suction hose of a vacuum pumper truck. The nozzle comprises a tubular housing and the rotor within the housing near the intake end. The rotor includes a hollow cylindrical canister and spiral vanes on its exterior. Ambient air enters an air tube, penetrates the side of the housing and supplies ambient air to the interior of the canister. The air exits through outlet ports into the liquid waste as it moves past under vacuum. The injected air reduces the density of the liquid waste, speeding up the pumping process and reducing the incidence of blockages.

Abstract: This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3-hydroxymethyl-4-[1-methyl-5-(1?-methyl-1?,2?,3?,4?,5?,6?-hexahydro-[3,4?]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2-hydroxy methyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2-ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.

Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

Abstract: Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

Abstract: A macerator (32), e.g. for sewerage, including two stacks of interleaved contra-rotating cutters and spacers is mounted in a macerator chamber (30) having an inlet (60) and an outlet (62). The chamber (32) has a sump (80) upstream of the stacks of the cutters, which are mounted at such an angle that hard, solid material such as stones and metal fall under gravity through the influent into the sump.

Abstract: The invention is a screening device suitable for screening a liquid material having solid matter suspended in it, which comprises a number of sets of discs, the discs of each set being rigidly mounted on a shaft, with the discs on each shaft being separated from one another axially, means mounting the shafts about parallel axes, with the discs of adjacent shafts being interleaved with one another and means to cause the shafts to rotate independently in the same rotational sense such that successive shafts rotate progressively faster to cause the solid matter suspended in the liquid material to be moved in a direction from the slowest shaft to the fastest shaft. The device is used particularly in sewage processing plants.

Abstract: A method and apparatus for forming a cement or plaster slurry, for example, for use in mines, in which bags of cement or plaster are fed into a substantially closed chamber, are ruptured, and water is fed into the chamber at a controlled rate. The resulting mixture is fed into a macerator which serves to comminute the bag material and to mix the cement or plaster which is then fed into a pump, preferably a positive displacement pump, such as a helical gear pump and is thus pumped on to the point of use.