Patents by Inventor Christopher Switzer

Christopher Switzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense oligonucleitide containing compositions and method of forming duplexes
    Patent number: 6031086
    Abstract: Replacement of the natural nucleotides with unnatural zwitterionic nucleotides having a cationic moiety tethered to the base (or analog thereof) results in oligodeoxynucleotides with diminished charge but undiminished ability to complex with DNA at low ionic strengths. We have now discovered that DNA can be made fully zwitterionic by introducing tethered cationic moieties to the bases without affecting duplex formation. The resulting oligonucleotides have the further advantages of being nuclease resistant.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: February 29, 2000
    Assignee: The Regents of the University of California
    Inventor: Christopher Switzer
  • Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
    Patent number: 5596091
    Abstract: Replacement of the natural nucleotides with unnatural zwitterionic nucleotides having a cationic moiety tethered to the base (or analog thereof) results in oligodeoxynucleotides with diminished charge but undiminished ability to complex with DNA at low ionic strengths. We have now discovered that DNA can be made fully zwitterionic by introducing tethered cationic moieties to the bases without affecting duplex formation. The resulting oligonucleotides have the further advantages of being nuclease resistant.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: January 21, 1997
    Assignee: The Regents of the University of California
    Inventor: Christopher Switzer