Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genetic alterations. In particular, a method is provided for that includes obtaining a set of sequence reads. The sequence reads each include a single molecule barcode (SMB) sequence that is a non-random oligonucleotide sequence. The method further includes assigning the sequence reads to read groups according to a read group signature. The read group signature comprises an SMB sequence and a start and end position of a nucleic acid fragment from the circulating cell free sample nucleic acid. The sequence reads comprising start and end positions and an SMB sequence similar to the read group signature are assigned to a read group. The method further includes generating a consensus for each read group, and determining the presence or absence of a genetic alteration based on the consensus for each read group.

Abstract: A desk assembly (10) comprises a base (12) adapted to stably engage a floor surface. An upright support member (14) is secured to and extends upwardly from the base. A planar desk (34) is connected in slidable engagement to the support member (14) between a lower (L) and an upper position (U). Biasing means, preferably a gas spring (100), is connected between the base (12) and the desk (34). The biasing means biases the desk upwardly from said lower position (L) toward said upper position (U). Locking means is operable to selectively secure said desk intermediate said lower and upper positions. The provision of an upwardly biased force by biasing means, between the upper and lower positions, improves convenience for the user when adjusting height of the desk.