Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: Methods to use a tool for dimensional verification of a vehicle frame suspension system bracket pocket having first and second cam slots, the tool including a first sub-assembly configured for insertion through and registration of the first cam slot; a second sub-assembly configured for insertion through and registration of the second cam slot; and an intermediate sub-assembly disposed between and attachable to the first and second sub-assemblies via a shaft, the intermediate sub-assembly including an extension rod receiving feature defining at least one extension rod receiving aperture; wherein the sub-assemblies lock against the bracket walls to define a horizontal center axis and are adjustable to determine and register a center point along an intersecting vertical center axis between the first and second cam slots that is alignable with the at least one extension rod receiving aperture.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: Methods to use a tool for dimensional verification of a vehicle frame suspension system bracket pocket having first and second cam slots, the tool including a first sub-assembly configured for insertion through and registration of the first cam slot; a second sub-assembly configured for insertion through and registration of the second cam slot; and an intermediate sub-assembly disposed between and attachable to the first and second sub-assemblies via a shaft, the intermediate sub-assembly including an extension rod receiving feature defining at least one extension rod receiving aperture; wherein the sub-assemblies lock against the bracket walls to define a horizontal center axis and are adjustable to determine and register a center point along an intersecting vertical center axis between the first and second cam slots that is alignable with the at least one extension rod receiving aperture.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: Provided herein are compounds of Formula I: in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, which are DP2 receptor modulators useful in the treatment of immunologic diseases.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Abstract: Fixtures and methods are described herein to measure fastener stretch after fastener application. The measurement fixtures may include fastener contacting portions having contact plates that may move orbitally about a measurement shaft to allow contact plates to abut against non-parallel end surfaces of a fastener. The fixtures may also include datum assemblies that have datum plate mounted in fixed relation to the contacting portions that allow for measurements to be made between the datum plates. Adjustable dials may be included to transfer rotational movement of the dial to translation movement of the contacting portions. Measurement fixtures may further include a frame and mounting portions.

Abstract: Fixtures and methods are described herein to measure fastener stretch after fastener application. The measurement fixtures may include fastener contacting portions having contact plates that may move orbitally about a measurement shaft to allow contact plates to abut against non-parallel end surfaces of a fastener. The fixtures may also include datum assemblies that have datum plate mounted in fixed relation to the contacting portions that allow for measurements to be made between the datum plates. Adjustable dials may be included to transfer rotational movement of the dial to translation movement of the contacting portions. Measurement fixtures may further include a frame and mounting portions.

Abstract: Provided herein are compounds of Formula I: in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, which are DP2 receptor modulators useful in the treatment of immunologic diseases.

Abstract: Provided herein is a method of treating an allergic inflammatory disease selected from asthma, dermatitis, allergic rhinitis, urticaria, anaphylaxis, angioedemea, allergies, contact hypersensitivity, drug hypersensitivity, and allergic conjunctivitis in a mammal, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, to said mammal in need thereof, wherein A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 are as defined herein.

Abstract: Provided herein is a method of treating an allergic inflammatory disease selected from asthma, dermatitis, allergic rhinitis, urticaria, anaphylaxis, angioedemea, allergies, contact hypersensitivity, drug hypersensitivity, and allergic conjunctivitis in a mammal, comprising administering a therapeutically effective amount of a compound of Formula I or a pharmaceutically acceptable salt thereof, to said mammal in need thereof, wherein A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 are as defined herein.

Abstract: Compounds of Formula I: (I) in which A, A1, R1, R7a, R7b, R8 and R10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D2 (PGD2). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.

Abstract: A compound having the formula: is useful in the preparation of compounds of Formula I.