Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: A method of concentrating a process fluid, including a carrier fluid, including: (a) maintaining a process fluid at a predetermined temperature value/range; (b) evaporating the carrier fluid from the process fluid to produce a concentrated process fluid; (c) monitoring at least one process variable of steps (a) or (b) to detect fouling formed in either step (a) or (b); and (d) initiating a cleaning protocol if the process variable deviates from a predetermined value/range to reduce the fouling formed.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of JAK2 enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with JAK2 signaling with the compounds and compositions of the disclosure.

Abstract: A gimbal assembly for supporting a camera includes a first member, a second member, a third member and a frame. The first member is arranged to support the camera and pivotally supported on the second member so as to rotate about a yaw axis with respect to the second member, the second member is pivotally supported on the third member so as to rotate about a pitch axis with respect to the third member, the pitch axis being orthogonal to the yaw axis, and the third member is pivotally supported on the frame so as to rotate about a roll axis with respect to the frame, the roll axis being orthogonal to the pitch axis and to the yaw axis. The third member is coupled with the frame so that it slides on an internal surface of the frame when the third member rotates about the roll axis.

Abstract: A rail element (10, 33) for a camera slider system or, more generally, a tube joiner for a rail comprised of an expansion device (23, 30), located internally at an open end (12, 32) of a tubular body (11, 33). The expansion device is configured to fit within a male part or joiner element (16, 31) that may be inserted into the end of the tube (10, 33) and can be actuated to an expanded state where it exerts force radially outwards through the joiner (16, 31) to hold it against the open end (12, 32), thereby joining two tubular or rail element ends together.

Abstract: A method of concentrating a process fluid, including a carrier fluid, including: (a) maintaining a process fluid at a predetermined temperature value/range; (b) evaporating the carrier fluid from the process fluid to produce a concentrated process fluid; (c) monitoring at least one process variable of steps (a) or (b) to detect fouling formed in either step (a) or (b); and (d) initiating a cleaning protocol if the process variable deviates from a predetermined value/range to reduce the fouling formed.

Abstract: A quick release mount system having a mounting plate with opposed sides, each includes latching surfaces, adapted to be received into a base member having a socket. The mounting system further includes at least one movable latching member for engaging with the latching surface of the mounting plate to prevent separation of the mounting plate from the socket. The mounting system also includes a locking mechanism for clamping said mounting plate within the socket, by pushing the mounting plate in a direction perpendicular to the base, and against the at least one latching member.

Abstract: A rail element (10, 33) for a camera slider system or, more generally, a tube joiner for a rail comprised of an expansion device (23, 30), located internally at an open end (12, 32) of a tubular body (11, 33). The expansion device is configured to fit within a male part or joiner element (16, 31) that may be inserted into the end of the tube (10, 33) and can be actuated to an expanded state where it exerts force radially outwards through the joiner (16, 31) to hold it against the open end (12, 32), thereby joining two tubular or rail element ends together.

Abstract: A quick release mount system having a mounting plate with opposed sides, each includes latching surfaces, adapted to be received into a base member having a socket. The mounting system further includes at least one movable latching member for engaging with the latching surface of the mounting plate to prevent separation of the mounting plate from the socket. The mounting system also includes a locking mechanism for clamping said mounting plate within the socket, by pushing the mounting plate in a direction perpendicular to the base, and against the at least one latching member.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Abstract: A method of machining a fibrous sheet for a composite structure is described. The sheet comprises a resin matrix having a glass transition temperature, wherein the method comprises cooling the sheet substantially to maintain the temperature of the matrix below its glass transition temperature during machining.

Abstract: A method of machining a fibrous sheet for a composite structure is described. The sheet comprises a resin matrix having a glass transition temperature, wherein the method comprises cooling the sheet substantially to maintain the temperature of the matrix below its glass transition temperature during machining.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

Abstract: The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.