Patents by Inventor Christopher Trabbic

Christopher Trabbic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of ERCC1-XPF and methods of using the same
    Patent number: 9821008
    Abstract: Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: November 21, 2017
    Assignee: The University of Toledo
    Inventors: Stephan M. Patrick, Paul W. Erhardt, Christopher Trabbic
  • INHIBITORS OF ERCC1-XPF AND METHODS OF USING THE SAME
    Publication number: 20160296556
    Abstract: Compositions and methods for inhibiting the DNA repair protein complex, ERCC1-XPF, and methods to enhance clinical responses to anticancer drugs that interact with DNA such as cisplatin, and to overcome drug resistance due to DNA repair mechanisms, are described.
    Type: Application
    Filed: November 25, 2014
    Publication date: October 13, 2016
    Applicant: The University of Toledo
    Inventors: Stephan M. PATRICK, Paul W. ERHARDT, Christopher TRABBIC
  • Materials and methods useful to induce vacuolization, cell death, or a combination thereof
    Patent number: 9061994
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: June 23, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Jean H. Overmeyer, Christopher Trabbic
  • Materials And Methods Useful To Induce Vacuolization, Cell Death, Or A Combination Thereof
    Publication number: 20150152049
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 4, 2015
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Jean H. Overmeyer, Christopher Trabbic
  • Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof
    Patent number: 9023871
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 5, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Christopher Trabbic, Jean H. Overmeyer
  • Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof
    Publication number: 20140213615
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Application
    Filed: April 7, 2014
    Publication date: July 31, 2014
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: William A. Maltese, Paul W. Erhardt, Christopher Trabbic, Jean H. Overmeyer