Patents by Inventor Christopher V. DeSimone
Christopher V. DeSimone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969197Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.Type: GrantFiled: October 15, 2018Date of Patent: April 30, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. DeSimone, Samuel J. Asirvatham, Christopher J. McLeod
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Publication number: 20230139966Abstract: Devices and methods are described for disinfection of pathogenic organisms using pulsed DC field electroporation. For example, this disclosure describes disinfection of pathogenic organisms using pulsed DC field electroporation for lung infection treatment, blood infection treatment, sterilization, and respirators.Type: ApplicationFiled: April 12, 2021Publication date: May 4, 2023Inventors: Hideki Ebihara, Jason A. Tri, Kalpathi L. Venkatachalam, Paul A. Friedman, Christopher V. DeSimone, Daniel C. DeSimone, Martin van Zyl, Adetola O. Ladejobi, Andrew D. Badley, Samuel J. Asirvatham
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Publication number: 20220346870Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.Type: ApplicationFiled: July 18, 2022Publication date: November 3, 2022Applicant: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, JR., Samuel J. Asirvatham, Christopher V. DeSimone
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Patent number: 11426233Abstract: Embodiments of the present disclosure relate to treating diseased tissue with ablation therapy. In an embodiment, an apparatus comprises a catheter having an elongate body extending between a proximal end and a distal end. The apparatus further includes a balloon structure arranged proximal to the distal end of the catheter, wherein the balloon structure has a first portion with a first permeability and a second portion with a second permeability such that the first permeability is different than the second permeability. In addition, the apparatus includes a first electrode arranged on or within the balloon structure and configured to: transmit current through the first portion, receive current transmitted through the first portion or both.Type: GrantFiled: June 5, 2018Date of Patent: August 30, 2022Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and ResearchInventors: Sarah M. Gruba, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Chance M. Witt, Deepak Padmanabhan, Christopher V. DeSimone
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Patent number: 11337637Abstract: Systems, methods, devices, and techniques for analyzing and applying features of a T-wave derived from an electrocardiogram. A computing system can receive a set of data that characterizes an electrocardiogram of a patient. The system can analyze the set of data to identify a T-wave that occurs in the electrocardiogram. The system can determine values of one or more features of the T-wave and provide the information that identifies the values of the one or more features of the T-wave to a user.Type: GrantFiled: August 31, 2017Date of Patent: May 24, 2022Assignee: Mayo Foundation for Medical Education and ResearchInventors: Peter A. Noseworthy, Bo Qiang, Paul A. Friedman, Alan M. Sugrue, Vaclav Kremen, Bryan L. Striemer, Charles J. Bruce, Virend K. Somers, Kevin E. Bennet, Michael J. Ackerman, Samuel J. Asirvatham, John J. Dillon, Christopher V. DeSimone
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Patent number: 11337749Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.Type: GrantFiled: October 7, 2016Date of Patent: May 24, 2022Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Christopher V. DeSimone, Barham K. Abu Dayyeh, Samuel J. Asirvatham
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Publication number: 20220071700Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.Type: ApplicationFiled: November 17, 2021Publication date: March 10, 2022Inventors: Christopher V. DESIMONE, Barham K. ABU DAYYEH, Samuel J. ASIRVATHAM
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Publication number: 20210275080Abstract: Systems, methods, devices, and techniques for analyzing and applying features of a T-wave derived from an electrocardiogram. A computing system can receive a set of data that characterizes an electrocardiogram of a patient. The system can analyze the set of data to identify a T-wave that occurs in the electrocardiogram. The system can determine values of one or more features of the T-wave and provide the information that identifies the values of the one or more features of the T-wave to a user.Type: ApplicationFiled: August 31, 2017Publication date: September 9, 2021Applicant: Mayo Foundation for Medical Education and ResearchInventors: Peter A. Noseworthy, Bo Qiang, Paul A. Friedman, Alan M. Sugrue, Vaclav Kremen, Bryan L. Striemer, Charles J. Bruce, Virend K. Somers, Kevin E. Bennet, Michael J. Ackerman, Samuel J. Asirvatham, John J. Dillon, Christopher V. DeSimone
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Publication number: 20210275081Abstract: An apparatus and computerized method accurately distinguishes VT and SWCT without the need for manual ECG, electrogram (EMG) and/or vectorcardiogram (VCG) interpretation or calculation. The apparatus and computerized method provides three types of wide complex beat differentiation that can be automatically implemented using data provided by ECG, EMG and/or VCG interpretation software. The first type is based in whole or in part on a WCT Formula. The second type is based in whole or in part on a VT prediction model. The third type is based in whole or in part on an analysis of ventricular repolarization (e.g., T wave).Type: ApplicationFiled: August 15, 2019Publication date: September 9, 2021Inventors: Adam M. May, Christopher V. Desimone, Abhishek J. Deshmukh
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Patent number: 11020589Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.Type: GrantFiled: March 27, 2019Date of Patent: June 1, 2021Assignee: Mayo Foundation for Medical Education and ResearchInventors: Faisal F. Syed, Charles J. Bruce, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham, Tomas Kara, Pavel Leinveber, Miroslav Novak, Zdenek Starek, Jiri Wolf
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Publication number: 20200305946Abstract: This document describes methods and devices for treating ventricular fibrillation. For example, this document describes methods of performing electroporation of a ventricle and electroporation catheters. The methods can include inserting a distal end portion of a catheter into a ventricle of a heart of a patient, inflating a balloon coupled to the distal end portion of the catheter, occluding a valve of the heart associated with the ventricle with the balloon, injecting a fluid into the ventricle via an aperture defined by the distal end portion of the catheter, and generating an electrical current via an electrode on the distal end portion of the catheter.Type: ApplicationFiled: October 15, 2018Publication date: October 1, 2020Applicant: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. DeSimone, Samuel J. Asirvatham, Christopher J. McLeod
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Publication number: 20200147361Abstract: Devices and methods can be used to treat dermatologic disorders using low dose DC electroporation. Such electroporation is essentially non-thermal modulation. In some implementations, the devices and methods described herein can be used for anti-aging treatments. In some implementations, the devices and methods described herein can be used for detecting/screening of various types of skin cancers. In some implementations, the devices and methods described herein can be used for therapy delivery for the treatment of early or pre-malignant skin cancers.Type: ApplicationFiled: April 30, 2018Publication date: May 14, 2020Applicant: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. DeSimone, Samuel J. Asirvatham
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Publication number: 20190224477Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.Type: ApplicationFiled: March 27, 2019Publication date: July 25, 2019Applicants: Mayo Foundation for Medical Education and ResearchInventors: Faisal F. Syed, Charles J. Bruce, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham, Tomas Kara, Pavel Leinveber, Miroslav Novak, Zdenek Starek, Jiri Wolf
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Patent number: 10279170Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.Type: GrantFiled: March 20, 2015Date of Patent: May 7, 2019Assignees: Mayo Foundation for Medical Education and Research, St. Anne's University Hospital BrnoInventors: Faisal F. Syed, Charles J. Bruce, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham, Tomas Kara, Pavel Leinveber, Miroslav Novak, Zdenek Starek, Jiri Wolf
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Publication number: 20180360531Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.Type: ApplicationFiled: October 25, 2016Publication date: December 20, 2018Applicant: Mayo Foundation for Medical Education and ResearchInventors: David R. Holmes, Jr., Samuel J. Asirvatham, Christopher V. DeSimone
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Publication number: 20180344393Abstract: Embodiments of the present disclosure relate to treating diseased tissue with ablation therapy. In an embodiment, an apparatus comprises a catheter having an elongate body extending between a proximal end and a distal end. The apparatus further includes a balloon structure arranged proximal to the distal end of the catheter, wherein the balloon structure has a first portion with a first permeability and a second portion with a second permeability such that the first permeability is different than the second permeability. In addition, the apparatus includes a first electrode arranged on or within the balloon structure and configured to: transmit current through the first portion, receive current transmitted through the first portion or both.Type: ApplicationFiled: June 5, 2018Publication date: December 6, 2018Inventors: Sarah M. Gruba, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Chance M. Witt, Deepak Padmanabhan, Christopher V. DeSimone
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Publication number: 20180296264Abstract: Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.Type: ApplicationFiled: October 7, 2016Publication date: October 18, 2018Applicant: Mayo Foundation for Medical Education and ResearchInventors: Christopher V. DeSimone, Barham K. Abu Dayyeh, Samuel J. Asirvatham
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Patent number: 10098695Abstract: Devices and methods are described for the treatment of heart conditions such as heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. Intraoperative test procedures for assessing the efficacy of the pericardial modification procedure are also described.Type: GrantFiled: November 18, 2016Date of Patent: October 16, 2018Assignee: Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Barry A. Borlaug, Christopher V. DeSimone, Prakriti Gaba
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Publication number: 20170258521Abstract: Devices and methods are described for the treatment of heart conditions such as heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. Intraoperative test procedures for assessing the efficacy of the pericardial modification procedure are also described.Type: ApplicationFiled: November 18, 2016Publication date: September 14, 2017Inventors: Samuel J. Asirvatham, Barry A. Borlaug, Christopher V. DeSimone, Prakriti Gaba
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Publication number: 20170056648Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.Type: ApplicationFiled: March 20, 2015Publication date: March 2, 2017Applicants: Mayo Foundation for Medical Education and Research, St. Anne's University Hospital BrnoInventors: Faisal F. Syed, Charles J. Bruce, Christopher V. DeSimone, Paul A. Friedman, Samuel J. Asirvatham, Tomas Kara, Pavel Leinveber, Miroslav Novak, Zdenek Starek, Jiri Wolf