Patents by Inventor Christopher W. Grote

Christopher W. Grote has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
    Patent number: 10604488
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 31, 2020
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
    Patent number: 10363251
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat a variety of disorders.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: July 30, 2019
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Substituted berbines and processes for their synthesis
    Patent number: 9856251
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: January 2, 2018
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Oxidative dearomatization of berbines
    Patent number: 9593111
    Abstract: The present disclosure provides oxidized berbine derivatives, processes for their preparation, and methods of using the oxidized berbine derivatives.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: March 14, 2017
    Assignee: Mallinckrodt LLC
    Inventor: Christopher W. Grote
  • (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
    Patent number: 9562014
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: February 7, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF
    Publication number: 20170029432
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
    Type: Application
    Filed: September 2, 2016
    Publication date: February 2, 2017
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • SUBSTITUTED BERBINES AND PROCESSES FOR THEIR SYNTHESIS
    Publication number: 20160347747
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Substituted berbines and processes for their synthesis
    Patent number: 9458109
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: October 4, 2016
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
    Patent number: 9296699
    Abstract: The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 29, 2016
    Assignee: MALLINCKRODT LLC
    Inventors: Christopher W. Grote, Joseph P. McClurg, John E. Johnson, Jr., Sarah M. Farris
  • OXIDATIVE DEAROMATIZATION OF BERBINES
    Publication number: 20150361076
    Abstract: The present disclosure provides oxidized berbine derivatives, processes for their preparation, and methods of using the oxidized berbine derivatives.
    Type: Application
    Filed: June 11, 2015
    Publication date: December 17, 2015
    Inventor: Christopher W. Grote
  • (+)-MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF
    Publication number: 20150335638
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat a variety of disorders.
    Type: Application
    Filed: July 31, 2015
    Publication date: November 26, 2015
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Substituted berbines and their synthesis
    Patent number: 9181237
    Abstract: The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: November 10, 2015
    Assignee: Mallinckrodt LLC
    Inventor: Christopher W. Grote
  • SUBSTITUTED BERBINES AND THEIR SYNTHESIS
    Publication number: 20150099772
    Abstract: The present invention provides substituted berbines, processes for the synthesis of substituted berbine compounds, as well as intermediates used in the synthesis of substituted berbine compounds. Also provided are methods for using the substituted berbines to inhibit cancer cell growth.
    Type: Application
    Filed: October 2, 2014
    Publication date: April 9, 2015
    Inventor: Christopher W. Grote
  • (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
    Patent number: 8946419
    Abstract: The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: February 3, 2015
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Amruta R. Poreddy
  • One-pot preparation of hexahydroisoquinolines from amides
    Patent number: 8921561
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: December 30, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • Preparation of N-alkylated opiates by reductive amination
    Patent number: 8729266
    Abstract: The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: May 20, 2014
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Brian Orr, Tao Jiang, Gary L. Cantrell
  • (+)-6-Hydroxy-Morphinan or (+)-6-Amino-Morphinan Derivatives
    Publication number: 20140031543
    Abstract: The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention.
    Type: Application
    Filed: October 3, 2013
    Publication date: January 30, 2014
    Applicant: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Amruta R. Poreddy
  • (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
    Patent number: 8563724
    Abstract: The present invention provides (+)-morphinanium compounds comprising substituted 6-hydroxy or 6-amine groups. The invention also provides methods for inhibiting microglial activation by administering the compounds of the invention.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 22, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Peter X. Wang, Bobby N. Trawick, David W. Berberich
  • (+)-morphinanium N-oxides and processes for their production
    Patent number: 8563727
    Abstract: The present invention provides (+)-morphinanium N-oxide compounds or pharmaceutically acceptable salts thereof. The invention also provides processes for producing (+)-morphinanium N-oxides or pharmaceutically acceptable salts thereof from the corresponding tertiary N-substituted (+)-morphinan compound or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 22, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Peter X. Wang, Bobby N. Trawick, Christopher W. Grote, David W. Berberich, Hang Sun, Subo Liao
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 8524904
    Abstract: The present invention is directed to the preparation of 6-hydroxy morphinans having formula (II) or N-alkylated 6-hydroxy morphinans having formula (III).
    Type: Grant
    Filed: December 3, 2009
    Date of Patent: September 3, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson