Patents by Inventor Christopher W. Helsen

Christopher W. Helsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20210130435
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: January 12, 2021
    Publication date: May 6, 2021
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • T CELL-ANTIGEN COUPLER WITH Y182T MUTATION AND METHODS AND USES THEREOF
    Publication number: 20200392247
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: October 10, 2018
    Publication date: December 17, 2020
    Inventors: Christopher W. HELSEN, Jonathan BRAMSON, Anna DVORKIN-GHEVA, Galina F. DENISOVA, Ksenia BEZVERBNAYA, Kenneth Anthony MWAWASI
  • T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS
    Publication number: 20200308278
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: June 17, 2020
    Publication date: October 1, 2020
    Inventors: Jonathan Lorne BRAMSON, Christopher W. HELSEN, Joanne Alicia HAMMILL, Kenneth Anthony MWAWASI
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20200270330
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 27, 2020
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS
    Publication number: 20200261500
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Inventors: Jonathan Lorne BRAMSON, Christopher W. HELSEN, Joanne Alicia HAMMILL, Kenneth Anthony MWAWASI
  • T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS
    Publication number: 20200239571
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: March 20, 2020
    Publication date: July 30, 2020
    Inventors: Jonathan Lorne BRAMSON, Christopher W. HELSEN, Joanne Alicia HAMMILL, Kenneth Anthony MWAWASI
  • T cell-antigen coupler with various construct optimizations
    Patent number: 10640562
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: May 5, 2020
    Assignee: MCMASTER UNIVERSITY
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20200071377
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: August 21, 2019
    Publication date: March 5, 2020
    Inventors: Jonathan BRAMSON, Christopher W. HELSEN, Galina DENISOVA, Rajanish GIRI, Kenneth MWAWASI
  • T CELL-ANTIGEN COUPLER WITH VARIOUS CONSTRUCT OPTIMIZATIONS
    Publication number: 20200024345
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Application
    Filed: June 14, 2019
    Publication date: January 23, 2020
    Inventors: Jonathan Lorne BRAMSON, Christopher W. HELSEN, Joanne Alicia HAMMILL, Kenneth Anthony MWAWASI
  • Trifunctional T cell-antigen coupler and methods and uses thereof
    Patent number: 10435453
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: October 8, 2019
    Assignee: MCMASTER UNIVERSITY
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi
  • TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF
    Publication number: 20160368964
    Abstract: A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 22, 2016
    Inventors: Jonathan Bramson, Christopher W. Helsen, Galina Denisova, Rajanish Giri, Kenneth Anthony Mwawasi