Abstract: This disclosure concerns transcription cassettes comprising nucleic acid molecules comprising a nucleotide sequence encoding AP-4 subunits; vectors comprising said transcription cassettes; pharmaceutical compositions comprising said vector; and vectors or compositions for use in the treatment of AP-4-Hereditary Spastic Paraplegia.

Abstract: Redefining modular construction, our Modular Building System surpasses existing methods of both traditional and modular construction. Every component, meticulously crafted such that it may be robotically produced and assembled, ensures unmatched precision and efficiency. Each panel, guarantees seamless integration and flawless finishes. Fully-finished in factory settings, they drastically simplify the construction process by eliminating many traditional materials and components, while retaining ease of construction and transportability from factory to building site, for final assembly. Our system's prowess extends to design flexibility, enabling construction of expansive living spaces with ease. Furthermore, its eco-conscious design facilitates effortless deconstruction and reuse, reducing environmental impact and waste.

Abstract: An apparatus for delivering a mould including a first and a second part into a dosing position. The apparatus includes a reorientation conveyor portion comprising first and second opposed retainer members. At least one of the first and second retainer members includes a conveyor. The first and second retainer members are operable to form a separation therebetween and the reorientation conveyor portion is operable to receive the mould into the separation between the first and second retainer members with the first and second retainer members in a first orientation and then move the first and second retainer members into a second orientation while substantially maintaining the first part of the mould in the same position relative to the second part of the mould. The apparatus further includes a mould-separation portion. The reorientation conveyor portion is operable to at least partially eject the mould into the mould-separation portion when the first and second retainer members are in the second orientation.

Abstract: A method of media content discovery and playback, the method including receiving a query for media content items from a search client, the query including one or more user subscriber group identifiers and a plurality of search criteria, filtering a plurality of available media content items according to the query to generate a list of matching content items among the plurality of available media content items, returning the list of matching content items to the search client, receiving from the search client a selection token with a content item to subscriber group mapping, providing the token to a user rights manager, receiving a signature authentication from the user rights manager, and issuing a playback key to the search client.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: The present disclosure relates to transcription cassettes comprising nucleic acids encoding RuvBL1 and/or RuvBL2 and the use of said vectors in gene therapy for the treatment of neurodegenerative diseases that result from expression of polymorphic repeat expansions of the GGGGCC (SEQ ID NO: 5) hexanucleotide-repeat sequence in the first intron of the C9ORF72 gene; pharmaceutical compositions comprising said vectors and including uses and methods to treat neurodegenerative diseases.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A method of media content discovery and playback, the method including receiving a query for media content items from a search client, the query including one or more user subscriber group identifiers and a plurality of search criteria, filtering a plurality of available media content items according to the query to generate a list of matching content items among the plurality of available media content items, returning the list of matching content items to the search client, receiving from the search client a selection token with a content item to subscriber group mapping, providing the token to a user rights manager, receiving a signature authentication from the user rights manager, and issuing a playback key to the search client.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A method of providing a menu for accessing media assets may include defining an media asset menu, defining an media asset menu item, the menu item including visibility criteria, adding the menu item to the defined menu, storing the defined menu, and distributing the stored menu to client devices over a network. A method of providing a menu for accessing media assets may include defining a new a menu for accessing media assets, loading a menu template from storage, the loaded menu template comprising a plurality of menu items, for each menu item among the plurality of menu items, determining if visibility criteria specified for the menu item are met, upon determining that the visibility criteria specified for the menu item are met, adding the menu item to the menu, otherwise excluding the menu item from the menu, and displaying the menu.

Abstract: A method of presenting electronic media assets may include retrieving metadata for a plurality of electronic media assets over a computer network, determining if one or more media assets is a transactional media asset, adding the transactional media assets to a media asset list, determining if one or more media assets is a subscription media asset, adding the subscription media assets to the media asset list, determining if one or more media assets is a live event media asset, adding the live event media assets to the media asset list, determining if one or more media assets is a current linear media asset, adding the current linear media assets to the media asset list, determining if one or more media assets is a future linear media asset adding the future linear media assets to the media asset list, and presenting the media title list to the consumer.

Abstract: A computer device may include logic configured to detect a change in a digital video recorder (DVR) recording list associated with a customer and generate an updated DVR recording list based on the detected change. The logic may be further configured to generate a schedule for an update notification for a DVR device associated with the customer and send an update notification to the DVR device associated with the customer based on the generated schedule.

Abstract: A computer device may include logic configured to detect a change in a digital video recorder (DVR) recording list associated with a customer and generate an updated DVR recording list based on the detected change. The logic may be further configured to generate a schedule for an update notification for a DVR device associated with the customer and send an update notification to the DVR device associated with the customer based on the generated schedule.