Abstract: This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof, wherein the variables Ring A, X, R1a, R1b, R2, R3, R4, m, n, and p are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The disclosure further relates to the use of the compounds described herein as therapeutics for the treatment of diseases and conditions mediated by EGFR proteins and/or PI3K proteins, such as cancer and other diseases.

Abstract: Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.

Abstract: Provided herein are compounds that are useful in treating cancer.

Abstract: Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.

Abstract: Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.

Abstract: A system that includes an accelerometer configured to measure acceleration of a vehicle, a gyroscope configured to measure orientation of the vehicle, a memory having computer readable instructions, and a processor for executing the computer readable instructions. The computer readable instructions include performing at intervals: receiving acceleration data from the accelerometer; receiving orientation data from the gyroscope; combining the acceleration data and the orientation data to generate speed fluctuation and slope data for the vehicle; and transmitting the fluctuation and slope data to a controller of the vehicle. The controller utilizes the speed fluctuation and slope data to modulate an engine throttle of the vehicle.

Abstract: Provided herein are compounds that modulate EGFR and methods of using the same, for example to treat cancer.

Abstract: A system that includes an accelerometer configured to measure acceleration of a vehicle, a gyroscope configured to measure orientation of the vehicle, a memory having computer readable instructions, and a processor for executing the computer readable instructions. The computer readable instructions include performing at intervals: receiving acceleration data from the accelerometer; receiving orientation data from the gyroscope; combining the acceleration data and the orientation data to generate speed fluctuation and slope data for the vehicle; and transmitting the fluctuation and slope data to a controller of the vehicle. The controller utilizes the speed fluctuation and slope data to modulate an engine throttle of the vehicle.

Abstract: Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases and conditions wherein inhibition of MEK and PI3K provides a benefit, like cancers, also are disclosed.

Abstract: Dual inhibitors of MEK and PI3K and compositions containing the same are disclosed. Methods of using the dual MEK/PI3K inhibitors in the treatment of diseases and conditions wherein inhibition of MEK and PI3K provides a benefit, like cancers, also are disclosed.

Abstract: In one aspect, the invention provides a gas treatment apparatus (1) comprising a gas-flow path and a plurality of reactor units (5)-(7) through which gas to be treated may flow arranged in series along the path. The reactor units (5)-(7) are adapted to generate a non-equilibrium plasma. This aspect of the invention may be used for decomposing pollutant materials in a gas (e.g. air). When air is being treated, the apparatus of this aspect of the invention is advantageously provided, downstream of the final reactor unit in series, with at least one catalyst bed (8) incorporating a catalyst capable of decomposing ozone.

Abstract: The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

Abstract: Percussive impacts due to bird strikes upon the hollow fan blades 20 are a well known problem. These percussive impacts not only deform previous fan blades but also reduce their stiffness. In accordance with the present invention, hollow fan blades 20 incorporate a cavity 23 within which, a matrix 24 with embedded expandable elements 25, is located. Thus, upon a percussive impact these expandable elements 25 are released in order to create an internal pressure within the cavity 25 which acts outwardly in order to relieve deformation and also stiffen the blade 20 as a result of the over pressure within the cavity 23.