Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: A component for a wearable electronic device can include a housing defining an internal volume, a first connector that is removably attachable to a head-mounted display. the first connector configured to electrically connect to the head-mounted display. and a second connector that is removably attachable to a supplemental unit. the second connector configured to electrically connect to the supplemental unit. The component can include a stiffener disposed in the internal volume, and the stiffener can be flexible along a first axis and rigid along two axes that are perpendicular to the first axis and to each other. An operational component can be disposed in the internal volume, and the operational component can be electrically connected to at least one of the first connector or the second connector.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: Disclosed are compounds of general formula (I): and pharmaceutically acceptable salts thereof, formulations, methods and uses in, for example, the treatment of disease.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: A computer-implemented method of and a system for securely establishing control of a resource in a distributed ledger is disclosed. The distributed ledger comprises a first shard instantiated on one or more first processor(s) of a first system. The first shard is configured to respond to an instruction originating from a first party. The distributed ledger further comprises a second shard instantiated on one or more second processor(s) and configured to respond to an instruction originating from a second party. The method comprises creating, by means of the publishing of a record by the first system, the resource, wherein the publishing of the record occurs in response to an instruction originating from the first party, wherein the publishing of the record is to the first shard of the ledger, and wherein the publishing of the record establishes that control of the resource resides with the second party.

Abstract: Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.

Abstract: A method for automatically determining injury treatment relation to a motor vehicle accident comprises obtaining a plurality of images of a damaged motor vehicle, vehicle data describing the motor vehicle, occupant data describing an occupant who occupied the motor vehicle during the motor vehicle accident, and injury data from an electronic insurance claim associated with the motor vehicle accident, the injury data specifying an injury to the occupant; determining a delta velocity value for the damaged motor vehicle by applying a first machine learning model to the set of images of the damaged motor vehicle and the vehicle data; determining an injury severity score by applying a second machine learning model to the delta velocity value for the damaged motor vehicle, the vehicle data, and the occupant data; and automatically adjudicating the electronic insurance claim.

Abstract: A computer-implemented method for adjusting one or more electronic medical bills for a claimant injured in an accident comprises generating a user interface to be presented to a claims adjuster; receiving a first user input identifying a claimant; responsive to the first user input, retrieving and aggregating multiple electronic medical bills each having at least one line; generating one or more findings and multiple scenarios by providing the aggregated electronic medical bills as inference input to a trained machine learning model, wherein the trained machine learning model has been trained with historical electronic medical bills and corresponding findings and scenarios, wherein responsive to the inference input, the trained machine learning model outputs the one or more findings and the multiple scenarios, wherein the one or more findings represent rationales for approving, denying, or repricing, and wherein the multiple scenarios include cost estimates based on the one or more findings.

Abstract: A computer-implemented method comprises: receiving, from an insurer system, an electronic medical bill; generating a decision representing a workflow selected from a plurality of the workflows based on at least one of a plurality of decisioning factors describing the electronic medical bill by providing the electronic medical bill as an inference input to a trained machine learning model, wherein responsive to the inference input the trained machine learning model generates the decision representing a workflow, wherein the trained machine learning model has been trained with historical electronic medical bills and corresponding historical decisions, the workflows including a provider network workflow and a provider negotiations workflow, and routing the electronic medical bill accordingly.

Abstract: A microphone includes a housing. The microphone includes a windscreen coupled with the housing. The windscreen and the housing define a central volume. The microphone includes an audio module within the central volume. The audio module includes a receiver capsule, a carrier unit coupled with the receiver capsule, and a counterweight coupled with the carrier unit. The microphone includes a suspension element that is coupled with the housing and carrier unit to suspend the audio module within the central volume. The suspension element includes an inner body that contacts the carrier unit. The suspension element includes first and second flanges extending outward from the inner body. The first and second flange are fixedly coupled with the housing. A cross-section of the first and second flange includes an arched region that extends at least partially to an inner wall of the housing. The arched regions are oriented in opposite directions.

Abstract: A microphone includes a housing. The microphone includes a windscreen coupled with the housing. The windscreen and the housing define a central volume. The microphone includes an audio module within the central volume. The audio module includes a receiver capsule, a carrier unit coupled with the receiver capsule, and a counterweight coupled with the carrier unit. The microphone includes a suspension element that is coupled with the housing and carrier unit to suspend the audio module within the central volume. The suspension element includes an inner body that contacts the carrier unit. The suspension element includes first and second flanges extending outward from the inner body. The first and second flange are fixedly coupled with the housing. A cross-section of the first and second flange includes an arched region that extends at least partially to an inner wall of the housing. The arched regions are oriented in opposite directions.

Abstract: A microphone includes a housing. The microphone includes a windscreen coupled with the housing. The windscreen and the housing define a central volume. The microphone includes an audio module within the central volume. The audio module includes a receiver capsule, a carrier unit coupled with the receiver capsule, and a counterweight coupled with the carrier unit. The microphone includes a suspension element that is coupled with the housing and carrier unit to suspend the audio module within the central volume. The suspension element includes an inner body that contacts the carrier unit. The suspension element includes first and second flanges extending outward from the inner body. The first and second flange are fixedly coupled with the housing. A cross-section of the first and second flange includes an arched region that extends at least partially to an inner wall of the housing. The arched regions are oriented in opposite directions.

Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.

Abstract: A multi-functional well completion apparatus and method of operation thereof that offers the ability, in a single trip and with limited running tool manipulation, to perform downhole completion operations, such as gravel pack operations or sand control frac or other fluid stimulation operations is described. The well completion tool has multiple functions or operational positions by using a self-closing time delay valve without the need of service tools, thereby saving rig time, reducing operating costs and operational risks associated with tripping service tools into and out of a wellbore.

Abstract: A computer-implemented method of and a system for securely establishing control of a resource in a distributed ledger is disclosed. The distributed ledger comprises a first shard instantiated on one or more first processor(s) of a first system. The first shard is configured to respond to an instruction originating from a first party. The distributed ledger further comprises a second shard instantiated on one or more second processor(s) and configured to respond to an instruction originating from a second party. The method comprises creating, by means of the publishing of a record by the first system, the resource, wherein the publishing of the record occurs in response to an instruction originating from the first party, wherein the publishing of the record is to the first shard of the ledger, and wherein the publishing of the record establishes that control of the resource resides with the second party.

Abstract: A method for automatically determining injury treatment relation to a motor vehicle accident comprises obtaining a plurality of images of a damaged motor vehicle, vehicle data describing the motor vehicle, occupant data describing an occupant who occupied the motor vehicle during the motor vehicle accident, and injury data from an electronic insurance claim associated with the motor vehicle accident, the injury data specifying an injury to the occupant; determining a delta velocity value for the damaged motor vehicle by applying a first machine learning model to the set of images of the damaged motor vehicle and the vehicle data; determining an injury severity score by applying a second machine learning model to the delta velocity value for the damaged motor vehicle, the vehicle data, and the occupant data; and automatically adjudicating the electronic insurance claim.

Abstract: Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.