Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and pyridinium compounds.

Abstract: The present invention provides methods of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators, methods of preparing intermediates of pyrimidine cyclohexyl glucocorticoid receptor modulators, and thioether compounds.

Abstract: An electrofusion coupling for joining together two or more sections of pipe or for joining a section of pipe and a pipework fitting, said coupling comprising: (i) a first part (14) having a first internal diameter at a first end adapted to form a tight sliding fit with a first pipe section and a second internal diameter at a second end, larger than the first; (ii) a second part (14) having a first internal diameter at a frist end dadpted to form a tight sliding fit with a second pipe section and an outside diameter at a second end adapted to form a tight sliding fit with the second internal diameter of the first part such that the two parts can nest together tightly with an overlapping region; (iii) electrical heating elements (16, 17, 18) and electrical terminal connections being provided in the two parts such that the first part can be used independently of the second part to join a section of pipe to a pipework fitting or the first and second parts can be used in combination to join two adjacent sections o

Abstract: A fitting (21) for providing a substantially fluid-tight seal between an opening in a chamber wall (10) and a pipe (4) passing through said opening, said fitting comprising: (i) a tubular sleeve (22) adapted to pass through the opening in the chamber wall (10) and further adapted to allow the pipe (4) to pass through the sleeve (22); (ii) a flange (24), extending radially outwardly from the sleeve (22), a first surface (26) of the flange being configured to contact the chamber wall (10) around substantially the whole circumference of the opening and over substantially the whole first surface (26) of the flange; (iii) a first energy transfer means (28) incorporated in the flange (24) and situated at or near the first surface (26) of the flange, said energy transfer means (28) being adapted to heat the first surface (26) of the flange in order to form a substantially fluid tight seal between the wall (10) and the flange (24); characterised in that at least part of the tubular sleeve (22) is tight sliding fit wi