Abstract: This document relates to methods and materials for treating a mammal (e.g., a human) having, or at risk of developing, a polycystic disease (e.g., a polycystic kidney disease (PKD)). For example, methods and materials that can be used to increase a level of polycystin-1 (PC-1) polypeptides and/or polycystin-2 (PC-2) polypeptides within a mammal having, or at risk of developing, a polycystic disease) are provided. In some cases, nucleic acid designed to increase a level of PC-1 polypeptides and/or PC-2 polypeptides within a mammal can be administered to a mammal having, or at risk of developing, a polycystic disease to treat the mammal.

Abstract: This document provides methods and materials involved in targeting adenoviruses. For example, this document provides nucleic acid molecules encoding a ?-carboxylated glutamic acid (GLA) domain of a factor X (fX) polypeptide, polypeptides having a GLA domain of a fX polypeptide, adenoviruses containing such nucleic acid molecules, adenoviruses containing such polypeptides, adenoviruses containing such nucleic acid molecules and such polypeptides, and compositions containing therapeutic adenoviral vectors and polypeptides having a GLA domain of an fX polypeptide. In addition, methods and materials for using adenoviruses as viral vectors to deliver nucleic acid to cells other than hepatocytes in vivo, methods and materials for using adenoviruses as vaccines, and methods and materials for using adenoviruses to treat cancer are provided.

Abstract: A method and a system for providing automatic teller machine (“ATM”) services to the customers of multiple financial institutions where the financial institutions contract with an ATM services provider. The ATM services provider providing multiple ATM's which are connected to an electronic funds transfer network. In an exemplary embodiment, the contracting financial institutions pay fees to the services provider in return for the services provider providing the financial institutions' customers with reduced or no cost ATM access. By contracting out the same set of ATMs to multiple financial institutions, the ATM services provider reduces duplicate ATM costs incurred when each financial institution maintains its own ATM network. Preferably, each of the ATMs of the ATM services provider has similar distinguishing characteristics or “trade dress” so as to make the ATM services provider's ATMs readily distinguishable from other ATMs.