Patents by Inventor Christopher Yallop

Christopher Yallop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
    Publication number: 20070031932
    Abstract: The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Application
    Filed: October 9, 2006
    Publication date: February 8, 2007
    Applicant: Crucell Holland B.V.
    Inventor: Christopher Yallop
  • Cultures of E1-immortalized cells and processes for culturing the same to increase product yields therefrom
    Publication number: 20060240513
    Abstract: The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant antibodies.
    Type: Application
    Filed: October 26, 2005
    Publication date: October 26, 2006
    Applicant: Crucell Holland B.V.
    Inventor: Christopher Yallop
  • Fed-batch process for production of erythropoietin in human embryonic retina cells that express adenovirus E1A
    Publication number: 20060121611
    Abstract: The invention provides processes for recombinant production of erythropoietin (EPO) in a human embryonic retina cell that expresses at least an adenoviral E1A protein, wherein said EPO is produced at high concentrations and wherein said EPO as produced has a high average sialic acid content per EPO molecule.
    Type: Application
    Filed: January 13, 2006
    Publication date: June 8, 2006
    Applicant: Crucell Holland B.V.
    Inventor: Christopher Yallop
  • Recombinant expression of factor VIII in human cells
    Publication number: 20060099685
    Abstract: The invention discloses a process for recombinant production of blood coagulation Factor VIII in an immortalized human embryonic retina cell, said cell expressing at least an adenoviral E1A protein and comprising a nucleic acid sequence encoding said Factor VIII, said nucleic acid sequence being under control of a heterologous promoter, said process comprising culturing said cell and expressing the Factor VIII in said cell, and harvesting the expressed Factor VIII. Cells that can be used in the process of the invention are also provided.
    Type: Application
    Filed: November 15, 2005
    Publication date: May 11, 2006
    Inventors: Christopher Yallop, Dirk Opstelten, Abraham Bout