Abstract: A building monitoring system includes a first sensor configured to detect a first condition in the space, a second sensor configured to detect a second condition in the space, and a robotic sentinel. The robotic sentinel includes a memory for storing one or more rules each configured to identify an alert condition for the space based on the first and/or second conditions in the space, a communications module configured to communicate with a remote device over a network, and a controller operatively coupled to the sensors, the memory, and the communications module. The controller is configured to apply the one or more rules to the first and second detected conditions in the space to identify one or more alert conditions and determine what action is required by the robotic sentinel, and if action is required, command the robotic sentinel to travel to a location of the alert condition.

Abstract: The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing human readable diagnostic test results (e.g., results from Point-of-Care testing and self-testing). The present disclosure provides methods, systems, and non-transitory computer-readable media for collecting, storing, assessing, and managing images and image results. The systems and methods facilitate unbiased verification and notification of test and image results.

Abstract: A system for assigning resources to workloads based on return on investment (ROI) comprises receiving a plurality of job requests and determining a cost and a revenue associated with processing the job requests using local resources and determining a cost and a revenue associated with processing the job requests using resources communicatively coupled over a network. The cost of using resources communicatively coupled over a network may fluctuate, even throughout a day such that the ROI for a job request may vary accordingly. Embodiments may continuously monitor costs and assign resources based on ROI.

Abstract: Provided herein are methods and compositions related to the treatment or prevention of cancer (e.g., by targeting a tumor in a subject with cancer) by administering to a subject an agent that inhibits autophagy. In certain aspects, provided herein are methods of compositions related to methods of sensitizing cancer cells to tumor necrosis factor-alpha (TNF-?) mediated killing by contacting the cells or administering the agent that inhibits autophagy.

Abstract: A system for controlling a hemostasis valve includes a hemostasis valve having a body portion having a proximal end, a distal end and a lumen extending between the proximal end and the distal end. The hemostasis value further includes at least one valve positioned in the proximal end of the body portion and an engagement member operatively coupled to the at least one valve. The system further includes a first drive member coupled to the engagement member and a controller coupled to the first drive member. The controller is configured to control the first drive member to impart movement to the engagement member to open and close the at least one valve.

Abstract: In some embodiments, a system and a computer-implemented method for role-based collaborative design based on manufacturing constraints are disclosed.

Abstract: A control device for a power machine can be configured to receive operation data associated with a current operation of the electric power machine, determine, based on the operation data, a commanded direction of travel for the electric power machine, determine, based on the operation data, an orientation of the work element relative to the lift arm, perform a comparison of the orientation to an orientation criterion, and, in response to determining a forward commanded direction of travel and based on the comparison, determine a modified operation parameter for the electric power machine, and control the at least one of electrical actuators based on the modified operation parameter.

Abstract: A control device for a power machine can be configured to receive operation data associated with a current operation of the electric power machine, determine, based on the operation data, a commanded direction of travel for the electric power machine, determine, based on the operation data, an orientation of the work element relative to the lift arm, perform a comparison of the orientation to an orientation criterion, and, in response to determining a forward commanded direction of travel and based on the comparison, determine a modified operation parameter for the electric power machine, and control the at least one of electrical actuators based on the modified operation parameter.

Abstract: An implantable medical device configured to provide for an intracardiac function, the implantable medical device comprises a body, a sensor arrangement arranged on the body and configured to receive cardiac sense signals, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process cardiac sense signals received using the sensor arrangement to detect a signal deflection potentially indicative of an atrial event caused by atrial activity to obtain an atrial detection, to detect a signal deflection indicative of a ventricular event caused by ventricular activity succeeding said atrial detection, to determine an atrial-ventricular interval representing a time between the atrial detection and the ventricular event, and to identify the atrial detection as valid or invalid based on the atrial-ventricular interval.

Abstract: The invention provides compounds that degrade the epidermal growth factor receptor (EGFR) including mutant forms via the ubiquitination of the EGFR protein and subsequent proteasomal degradation. The compounds are useful for the treatment of various cancers.

Abstract: An implantable medical device configured to provide for an intracardiac function comprises a body, a sensor arrangement arranged on the body and configured to receive a cardiac sense signal, and a processing circuitry operatively connected to the sensor arrangement. The processing circuitry is configured to process the cardiac sense signal received using the sensor arrangement to detect, in a cardiac cycle, a first atrial event candidate based on a comparison of the cardiac sense signal with a sense threshold, to determine a modified sense threshold, to monitor, by comparing the cardiac sense signal to said modified sense threshold following the detection of the first atrial event candidate, whether in the same cardiac cycle a second atrial event candidate is detected.

Abstract: Systems, methods, and computer program products for producer-side prioritization of message processing. Producer-side prioritization of message processing may include receiving an input message according to a messaging protocol for communicating between software components, where the input message comprises message priority information for the input message, producing a command for a next step in the processing flow, the command including a target time determined using the message priority information from the input message, queuing the command in a command queue, selecting the command from the command queue based on a determination that the target time has expired, and processing the command.

Abstract: A method for data-driven professional network expansion techniques is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes accessing enterprise-level data corresponding to the user and the enterprise, extracting parameters associated with the user and the enterprise from the enterprise-level data, and automatically generating, based on the extracted parameters, the user's professional network and a list of suggested professional contacts.

Abstract: A method for friction reduction during professional network expansion is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a remote computing system operated by a user associated with an enterprise and surfacing a professional networking UI on a display of the remote computing system during execution of the enterprise application. The method includes generating parameters that are representative of a connection between the user and each suggested professional contact based on enterprise-level data corresponding to the user and each suggested professional contact and generating friction-reducing UI elements for each suggested professional contact based on the generated parameters.

Abstract: A method for integrated professional network expansion during employee onboarding is implemented via a computing system including a processor. The method includes executing, via a network, an enterprise application on a first remote computing system operated by an employer associated with an enterprise, as well as causing surfacing of a professional networking UI on a display of the first remote computing system during the execution of the enterprise application. The method also includes receiving, via the professional networking UI surfaced on the display of the first remote computing system, user input including a specification of onboarding parameters for an employee of the enterprise, where the onboarding parameters correspond to one or more professional networking intentions for the employee. The method further includes causing the enterprise application to be executed on a second remote computing system operated by the employee in accordance with the specified onboarding parameters.

Abstract: Systems and methods are provided for configuring automatic playback settings on a media playback device. A graphical user interface displays automatic playback settings and receives selections of customized settings for automatic playback. The settings can include context granularity for automatic playback, limiting autoplay to when the media playback device is connected to a wireless network, and activating an audible notification when automatic playback of media content is beginning. An initial queue of media content is selected for playback on the media playback device. The system ascertains whether autoplay is enabled for a particular situation. If autoplay is enabled, the system automatically generates a queue of media that is related to the initial queue and initiates playback on the media playback device after the initial queue concludes.

Abstract: A method for loop escape analysis includes receiving a set of executable computer instructions stored on a storage medium, and determining a number of inputs to a loop associated with a data structure, storage space that would be saved by compressing the data structure, and a size of new elements required to compress the data structure. Upon reaching an end of the loop, the method determines whether to compress the data structure based on a comparison between the size of the new elements and the saved storage space. In response to determining to compress the data structure, the method compresses the data structure.

Abstract: A method for loop escape analysis includes receiving a set of executable computer instructions stored on a storage medium, and determining a number of inputs to a loop associated with a data structure, storage space that would be saved by compressing the data structure, and a size of new elements required to compress the data structure. Upon reaching an end of the loop, the method determines whether to compress the data structure based on a comparison between the size of the new elements and the saved storage space. In response to determining to compress the data structure, the method compresses the data structure.

Abstract: A control device for a power machine can be configured to receive a request to initiate a power burst mode for the power machine, wherein the power burst mode defines one or more operational parameters for increasing an amount of power used by at least one of the plurality of electrical actuator. The control device may receive data associated with one or more operational conditions of the power machine and assess a power burst constraint associated with the power burst mode. In response to the power burst constraint being satisfied, the control device may control power to at least one of the plurality of electrical actuators according to the one or more operational parameters of the power burst mode.