Abstract: Abstract: The present invention discloses a pharmaceutical product comprising L-2,4-diaminobutyric acid (DAB) and prazosin for use in the treatment of cancer by administration to the tumor. The invention also discloses the use of the said at least two active agents in the manufacture of a medicament and methods for the treatment of a cancer comprising intratumoral administration of the pharmaceutical formulation using a novel way of delivery.

Abstract: A multifunctional surgical instrument (1) is provided. The multifunctional surgical instrument (1) comprises a proximal portion (13) and two legs (14), each leg comprising a distal end (11, 12), wherein a default position of the multifunctional surgical instrument is an open position, wherein the distal ends (11, 12) of the legs (14) do not meet in the open position, characterized in that each leg (14) comprises an aspiration half-channel (26, 27), the proximal portion (13) comprises an aspiration connection (29) and at least one of the distal ends (11, 12) comprises at least one aspiration orifice (28), wherein the two half-channels (26, 27) are configured to form an air-tight and water-tight continuous channel (25) connecting the at least one aspiration orifice (28) to the aspiration connection (29) when the multifunctional surgical instrument is in a fully closed position and are configured to open the aspiration channel (25) when the multifunctional surgical instrument is not in the fully closed position.

Abstract: A method of delivering a solution including at least one drug is provided. The method includes providing a fluid exchange catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a solution that includes at least one drug, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse the solution into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure. Also described is a method of unblocking a fluid exchange catheter.

Abstract: A fluid exchange system may include a control unit comprising a processor; a tube set attachment removably connected to the control unit, the tube set attachment comprising a tube set fluidly connected to a fluid source and a drainage receptacle; a catheter fluidly connected to the tube set; and at least one sensor positioned on at least one of the control unit and the tube set attachment, wherein the control unit may be configured to supply fluid to a patient through the tube set and drain fluid from the patient via the tube set, and wherein the control unit may be configured to receive measurements from the at least one sensor to adjust the supply of the fluid to the patient and the drainage of the fluid from the patient.

Abstract: A method of delivering a solution including at least one drug is provided. The method includes providing a fluid exchange catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a solution that includes at least one drug, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse the solution into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure. Also described is a method of unblocking a fluid exchange catheter.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: According to the invention, a fluid exchange catheter is provided, which catheter has a proximal end and a distal end, and comprises an obligatory lumen having a proximal end and a distal end, the distal end of the obligatory lumen having a closed shape, wherein a lumen wall of the obligatory lumen forms a distal wall portion at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening in the lumen wall. Furthermore, the catheter comprises at least one additional lumen having a proximal end and a distal end, the distal end being arranged inside the obligatory lumen remote from the distal end of the obligatory lumen such that fluid exiting the at least one additional lumen flows inside the distal end of the obligatory lumen.

Abstract: According to the invention, a fluid exchange catheter is provided, which catheter has a proximal end and a distal end, and comprises an obligatory lumen having a proximal end and a distal end, the distal end of the obligatory lumen having a closed shape, wherein a lumen wall of the obligatory lumen forms a distal wall portion at the distal end of the obligatory lumen, the distal wall portion comprising at least one lumen opening in the lumen wall. Furthermore, the catheter comprises at least one additional lumen having a proximal end and a distal end, the distal end being arranged inside the obligatory lumen remote from the distal end of the obligatory lumen such that fluid exiting the at least one additional lumen flows inside the distal end of the obligatory lumen.

Abstract: Provided is a device for securing an invasive medical implementation, such as a catheter, to a patient. The device generally combines an adherent surface that attaches the device to the skin and a flexible clasping means to grasp the catheter and reversibly secure it to the device.

Abstract: A catheter system that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The system has devices that control the infused liquid's pressure changes accordingly to the aspirated liquid's pressure changes, in order to allow accurate and safe fluid exchange flow control and create changes of pressures at the catheter's tip that do not allow the catheter's blockage.

Abstract: The invention provides a device for securing an invasive medical implementation, such as a catheter, to a patient. The device generally combines an adherent surface that attaches the device to the skin and a flexible clasping means to grasp the catheter and reversibly secure it to the device.

Abstract: A catheter system that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The system has devices that control the infused liquid's pressure changes accordingly to the aspirated liquid's pressure changes, in order to allow accurate and safe fluid exchange flow control and create changes of pressures at the catheter's tip that do not allow the catheter's blockage.

Abstract: A catheter that can be used for concurrent fluid infusion and aspiration in humans, animals and biological material, at a wide range of flow rates, without any blockage problems. The catheter is composed of two concentric tubes; their proximal ends are properly connected to the infusion equipment and the aspiration equipment respectively; the distal end of the catheter is covered by a filter or membrane or grid or mesh cage and contains a hydrodynamically moving device of concurrent infusion and aspiration. The inner tube is properly assembled to the moving infusion and aspiration device, which irrigates the space surrounding the catheter's tip, through the filter or membrane or grid or mesh cage cover preserving its permeability, while it helps, due to its motion, the aspiration through the outer tube.