Abstract: A fluid impervious wall skin provides an interstitial space. The wall is formed from a composite material, the composite material comprising a plurality of layers including:, a first layer of flexible material having adhesive on at least one surface thereof for attachment to a structural wall; a layer comprising a spacer; and a second layer of flexible material; the layers of the composite material are attached a structural wall and one to the other by adhesive between adjacent layers, and the spacer provides the interstitial space N between the said first and second layers of flexible material within the said composite material.

Abstract: The present invention relates to a method for determining sensitivity to a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor in a human subject having breast cancer, the method comprising determining in a sample from the subject the level of expression of 11 genes as defined in the claims. The present invention further provides kits of parts, nucleic acid arrays, and uses thereof for determining sensitivity to a CDK4/6 inhibitor in a human subject having breast cancer. The present invention also relates to methods of treating a human subject having breast cancer, comprising administering a therapeutically effective amount of the CDK4/6 inhibitor to the subject.

Abstract: A weld seam monitoring apparatus includes a layer of sealant applied to the area surrounding the weld seam; a first layer of sheet material adapted to provide an air space and overlying the weld seam; a second layer of sheet material overlying the first layer of sheet material; and a fluid impermeable sealant overlying the second layer of sheet material. An air tight space is formed between the second layer of sheet material and the weld seam. The apparatus further includes a vacuum source, and the air tight space is in fluid communication with the vacuum source. The apparatus further includes vacuum monitoring means configured to monitor the status of a vacuum created in the air tight space.

Abstract: A weld seam monitoring apparatus includes a layer of sealant applied to the area surrounding the weld seam; a first layer of sheet material adapted to provide an air space and overlying the weld seam; a second layer of sheet material overlying the first layer of sheet material; and a fluid impermeable sealant overlying the second layer of sheet material. An air tight space is formed between the second layer of sheet material and the weld seam. The apparatus further includes a vacuum source, and the air tight space is in fluid communication with the vacuum source. The apparatus further includes vacuum monitoring means configured to monitor the status of a vacuum created in the air tight space.

Abstract: A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour, the said method comprising the step of assaying a sample of a breast tumour from said patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.

Abstract: A method to determine the clinical outcome of breast tumor affecting a patient if treated with an antitumoral agent against breast tumor. The method includes the step of assaying a sample of a breast tumor from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumor with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.

Abstract: The present invention provides new target gene regions for use in prediction, prognosis, diagnosis and therapy of breast cancer, based on the differential methylation profile of said targets in samples from subjects with breast cancer and healthy subjects.

Abstract: The present invention is related to the methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score.

Abstract: A gene set, kit and method predict the efficiency of anthracyclines-based treatment of breast cancer.

Abstract: A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, and possibly 40, 45, 50, 55, 60, 65 genes or proteins, antibodies or hypervariable portion thereof directed against the proteins encoded by these genes.

Abstract: A method to determine the clinical outcome of breast tumour affecting a patient if treated with an antitumoural agent against breast tumour. The method includes the step of assaying a sample of a breast tumour from the patient for an expression level of selected genes, by contacting mRNA sequences from the cells of this breast tumour with a set of more than 3 nucleotide sequences related to human mutated PIK3CA.

Abstract: A gene or protein set includes at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 possibly 100, 105, 110 genes or proteins or the entire set or antibodies (or hypervariable portion thereof) directed against the proteins encoded by these genes.

Abstract: Gene-Based Algorithmic Cancer Prognosis relates to methods and systems for prognosis determination in tumor samples. The methods and systems measure gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a number c risk score.

Abstract: According to an embodiment of the invention, a system for identifying when a running speed of an integrated circuit is within an applied clock speed is provided. A monotonic circuit is configured to receive input data and transmit output data. A completion detection circuit is configured to generate a completion detection signal for the monotonic circuit. A comparator is configured to compare at least the completion detection signal and a clock signal, and configured to emit an error signal if the clock signal arrives before the completion detection signal. A synchronous circuit element is configured to receive at least a portion of the output data and configured to be clock driven by the clock signal. The error signal represents that the clock speed is faster than an operating speed of the monotonic circuit.

Abstract: A method of converting a Boolean logic circuit into an asynchronous multi-rail circuit is provided. A Boolean logic circuit is converted into a first multi-rail circuit using at least Shannon's expansion. The first multi-rail circuit is technology mapped into a second multi-rail circuit. Completion detection circuitry is added which receives the primary outputs of the second multi-rail circuit.

Abstract: According to one embodiment of the present invention, a system for identifying a running speed of an integrated circuit is provided. An asynchronous multi-rail circuit is configured to receive input data and transmit output data. A completion detection circuit is configured to generate a completion detection signal for the asynchronous multi-rail circuit. A variable clock generator configured to be driven by at least the completion detection signal. A synchronous circuit element configured to receive at least a portion of the output data and configured to be clock driven by a clock signal from the variable clock generator. A period of the clock signal represents a running speed of the asynchronous circuit.