Patents by Inventor Christos Tsaklakidis

Christos Tsaklakidis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolin-2-one derivatives
    Patent number: 11939314
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: March 26, 2024
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20230028687
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: October 12, 2021
    Publication date: January 26, 2023
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • Quinolin-2-one derivatives
    Patent number: 11186562
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 30, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • 5-Morpholin-4-yl-pyrazolo[4,3-b]pyridine derivatives
    Publication number: 20210355123
    Abstract: Compounds of the formula Ia and Ib in which R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: September 4, 2019
    Publication date: November 18, 2021
    Applicant: Merck Patent GmbH
    Inventors: Lars BURGDORF, Christos TSAKLAKIDIS
  • Quinolin-2-one derivatives
    Patent number: 11174241
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: November 16, 2021
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20200190054
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20200190055
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • Quinolin-2-one derivatives
    Patent number: 10669251
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: June 2, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Mathilde Muzerelle, Lars Burgdorf, Margarita Wucherer-Plietker, Paul Czodrowski, Christina Esdar, Christos Tsaklakidis
  • Tricyclic heterocylic derivatives
    Patent number: 10570149
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 25, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Lars Burgdorf, Dieter Dorsch, Christos Tsaklakidis
  • TRICYCLIC HETEROCYLIC DERIVATIVES
    Publication number: 20190300547
    Abstract: Compounds of the formula I in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of ATR, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 3, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Lars BURGDORF, Dieter DORSCH, Christos TSAKLAKIDIS
  • QUINOLIN-2-ONE DERIVATIVES
    Publication number: 20190023685
    Abstract: Compounds of the formula I in which X1, X2, X3, X4, R1, R2, R3, Q and Y have the meanings indicated in Claim 1, are inhibitors of c-Kit kinase, and can be employed for the treatment of cancer.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 24, 2019
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Mathilde MUZERELLE, Lars BURGDORF, Margarita WUCHERER-PLIETKER, Paul CZODROWSKI, Christina ESDAR, Christos TSAKLAKIDIS
  • 3-substituted cyclopentylamine derivatives
    Patent number: 10118919
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: November 6, 2018
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner
  • Hydroxystatin derivatives for the treatment of arthrosis
    Patent number: 10077288
    Abstract: The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries arthritis, pain, allodynia or hyperalgesia.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: September 18, 2018
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Markus Klein
  • Acylguanidines for treating osteoarthritis
    Patent number: 9884814
    Abstract: The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: February 6, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Christos Tsaklakidis, Markus Klein, Paul Czodrowski
  • 3-SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES
    Publication number: 20180022738
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Application
    Filed: September 6, 2017
    Publication date: January 25, 2018
    Applicant: Merck Patent GmbH
    Inventors: Christos TSAKLAKIDIS, Wolfgang STAEHLE, Birgitta LEUTHNER
  • Aminostatin derivatives for the treatment of arthrosis
    Patent number: 9839665
    Abstract: The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: December 12, 2017
    Assignee: Merck Patent GmbH
    Inventors: Markus Klein, Christos Tsaklakidis, Hans Guehring, Birgitta Leuthner
  • Piperazine derivatives as FASN inhibitors
    Patent number: 9809552
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Manja Friese-Hamim, Birgitta Leuthner, Dirk Wienke
  • 3-substituted cyclopentylamine derivatives
    Patent number: 9790216
    Abstract: Compounds of the formula I in which R, W, R1, R4, X1, X2, X3, X4 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: October 17, 2017
    Assignee: Merck Patent GmbH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner
  • 3-aminocyclopentane carboxamide derivatives
    Patent number: 9732032
    Abstract: Compounds of the formula I in which R1, R4, R, X1, X2, X3, X4, q and W have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: August 15, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Brigitta Leuthner, Paul Czodrowski
  • 1,3-Disubstituted cyclopentane derivatives
    Patent number: 9718785
    Abstract: Compounds of the formula I in which R, Y, R1, X1, X2, X3 and q have the meanings indicated in claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: August 1, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Christos Tsaklakidis, Wolfgang Staehle, Birgitta Leuthner, Thomas Fuchss