Patents by Inventor Christos TZITZILONIS

Christos TZITZILONIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240317818
    Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.
    Type: Application
    Filed: June 5, 2024
    Publication date: September 26, 2024
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Cynthia CECH, Tim CRAIG, Christos TZITZILONIS, Alexander YANG, Liv JENSEN, Charlotte YANG, Corissa HARRIS, Matthew DIPIETRO, Dhruti DALAL
  • Publication number: 20240199616
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: July 10, 2023
    Publication date: June 20, 2024
    Inventors: Brian R. BLANK, Jennifer PITZEN, Gang WANG, Walter S. WON, Christos TZITZILONIS, Jie Jack LI, Elena S. KOLTUN, Naing AAY, Andreas BUCKL, Kevin MELLEM, Christopher SEMKO, Ash JOGALEKAR, Gert KISS, Adrian GILL
  • Publication number: 20240166698
    Abstract: The present disclosure relates to relates methods and associated compositions that provide fast, efficient site-selective conjugation of a protein, such as the pore-forming protein ?-hemolysin, to a biomolecule, such as a DNA polymerase, and the use of such site-selective protein-biomolecule conjugates in nanopore devices and methods.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 23, 2024
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy GREMYACHINSKIY, Christos TZITZILONIS
  • Publication number: 20240101577
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: February 17, 2023
    Publication date: March 28, 2024
    Inventors: Elena S. KOLTUN, Naing N. AAY, Andreas BUCKL, Kevin T. MELLEM, Brian R. BLANK, Jennifer PITZEN, Gang WANG, Ashutosh S. JOGALEKAR, Walter S. WON, Christos TZITZILONIS, Jie Jack LI, Adrian Liam GILL, James Joseph CREGG
  • Publication number: 20240067636
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: April 5, 2023
    Publication date: February 29, 2024
    Inventors: Jie Jack LI, Elena S. KOLTUN, Adrian Liam GILL, Andreas BUCKL, Walter WON, Naing AAY, Kevin MELLEM, Christos TZITZILONIS, Ashutosh JOGALEKAR, James Joseph CREGG
  • Publication number: 20240010688
    Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.
    Type: Application
    Filed: August 15, 2023
    Publication date: January 11, 2024
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Cynthia CECH, Tim CRAIG, Christos TZITZILONIS, Alexander Yang, Liv JENSEN, Charlotte YANG, Corissa HARRIS, Matthew DIPIETRO, Dhruti DALAL
  • Publication number: 20210230232
    Abstract: The present disclosure relates to relates methods and associated compositions that provide fast, efficient site-selective conjugation of a protein, such as the pore-forming protein ?-hemolysin, to a biomolecule, such as a DNA polymerase, and the use of such site-selective protein-biomolecule conjugates in nanopore devices and methods.
    Type: Application
    Filed: April 9, 2021
    Publication date: July 29, 2021
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Dmitriy GREMYACHINSKIY, Christos TZITZILONIS
  • Publication number: 20200407372
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: June 11, 2020
    Publication date: December 31, 2020
    Inventors: Elena S. KOLTUN, Naing N. AAY, Andreas BUCKL, Kevin T. MELLEM, Brian R. BLANK, Jennifer PITZEN, Gang WANG, Ashutosh S. JOGALEKAR, Walter S. WON, Christos TZITZILONIS, Jie Jack LI, Adrian Liam GILL, James Joseph CREGG
  • Publication number: 20200392191
    Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.
    Type: Application
    Filed: July 10, 2020
    Publication date: December 17, 2020
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Cynthia CECH, Tim CRAIG, Christos TZITZILONIS, Alexander YANG, Liv JENSEN, Charlotte YANG, Corissa HARRIS, Matthew DIPIETRO, Dhruti DALAL
  • Publication number: 20200339552
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: April 10, 2020
    Publication date: October 29, 2020
    Inventors: Jie Jack LI, Elena S. KOLTUN, Adrian Liam GILL, Andreas BUCKL, Walter WON, Naing AAY, Kevin MELLEM, Christos TZITZILONIS, Ashutosh JOGALEKAR, James Joseph CREGG
  • Publication number: 20200325534
    Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicant: Roche Sequencing Solutions, Inc.
    Inventors: Timothy Kellogg CRAIG, Cynthia Ann CECH, Michael DORWART, Liv Elisabeth JENSEN, Marshall Winston PORTER, Christos TZITZILONIS, Alexander Hyun-min YANG
  • Publication number: 20200017511
    Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 16, 2020
    Inventors: Brian R. BLANK, Jennifer PITZEN, Gang WANG, Walter S. WON, Christos TZITZILONIS, Jie Jack LI, Elena S. KOLTUN, Naing AAY, Andreas BUCKL, Kevin MELLEM, Christopher SEMKO, Ash JOGALEKAR, Gert KISS, Adrian GILL
  • Publication number: 20190119745
    Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.
    Type: Application
    Filed: January 3, 2019
    Publication date: April 25, 2019
    Applicant: GENIA TECHNOLOGIES, INC.
    Inventors: Timothy Kellogg CRAIG, Cynthia Ann CECH, Michael DORWART, Liv Elisabeth JENSEN, Marshall Winston PORTER, Christos TZITZILONIS, Alexander Hyun-min YANG
  • Publication number: 20190002509
    Abstract: The present disclosure relates to relates methods and associated compositions that provide fast, efficient site-selective conjugation of a protein, such as the pore-forming protein ?-hemolysin, to a biomolecule, such as a DNA polymerase, and the use of such site-selective protein-biomolecule conjugates in nanopore devices and methods.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 3, 2019
    Applicant: GENIA TECHNOLOGIES, INC.
    Inventors: Dmitriy GREMYACHINSKIY, Christos TZITZILONIS
  • Publication number: 20180362594
    Abstract: The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.
    Type: Application
    Filed: September 20, 2016
    Publication date: December 20, 2018
    Applicant: GENIA TECHNOLOGIES, INC.
    Inventors: Cynthia CECH, Tim CRAIG, Christos TZITZILONIS, Alexander YANG, Liv JENSEN, Charlotte YANG, Corissa HARRIS
  • Publication number: 20170088890
    Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 30, 2017
    Inventors: Timothy Kellogg CRAIG, Cynthia Ann CECH, Michael DORWART, Liv Elisabeth JENSEN, Marshall Winston PORTER, Christos TZITZILONIS, Alexander Hyun-min YANG