Patents by Inventor Christy Holland

Christy Holland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease
    Patent number: 11007284
    Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: May 18, 2021
    Assignee: University of Cincinnati
    Inventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
  • Gas-Encapsulated Acoustically Responsive Stabilized Microbubbles and Methods for Treating Cardiovascular Disease
    Publication number: 20200000945
    Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.
    Type: Application
    Filed: September 3, 2019
    Publication date: January 2, 2020
    Inventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
  • Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
    Patent number: 10500227
    Abstract: Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio of about 1:1 by volume, wherein X is greater than or equal to 3, are disclosed, along with methods for treating a patients suffering from cardiovascular disease by administering the ELIP at a site remote from the target diseased section, monitoring presence of the ELIP at the target diseased section, and administering ultrasound upon detection of presence such that bioactive NO is released at the target diseased section.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: December 10, 2019
    Assignee: University of Cincinnati
    Inventors: Christy Holland, Jason Raymond, Jonathan Sutton
  • Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease
    Patent number: 10456483
    Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: October 29, 2019
    Assignee: University of Cincinnati
    Inventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
  • Gas-Encapsulated Acoustically Responsive Stabilized Microbubbles and Methods for Treating Cardiovascular Disease
    Publication number: 20180036437
    Abstract: Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula CxFy in a volume ratio of from about 10:1 to about 1:10, wherein X is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.
    Type: Application
    Filed: October 19, 2017
    Publication date: February 8, 2018
    Inventors: Christy Holland, Himanshu Shekhar, Arunkumar Palaniappan
  • BIOACTIVE GAS-ENCAPSULATED ECHOGENIC LIPOSOMES AND METHODS FOR TREATING CARDIOVASCULAR DISEASE
    Publication number: 20160250252
    Abstract: Echogenic liposomes (ELIP) formulated with an at least partially pegylated phospholipid bi-layer shell, encapsulated nitric oxide, and encapsulated perfluorocarbon of the formula CxFy in a ratio of about 1:1 by volume, wherein X is greater than or equal to 3, are disclosed, along with methods for treating a patients suffering from cardiovascular disease by administering the ELIP at a site remote from the target diseased section, monitoring presence of the ELIP at the target diseased section, and administering ultrasound upon detection of presence such that bioactive NO is released at the target diseased section.
    Type: Application
    Filed: December 3, 2015
    Publication date: September 1, 2016
    Inventors: Christy Holland, Jason Raymond, Jonathan Sutton