Patents by Inventor Christy K. Holland
Christy K. Holland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11950792Abstract: An intravascular ultrasound (IVUS) catheter-based device for targeted delivery of ultrasound-activated emulsions of oxygen-scavenging droplets into a bloodstream of patients suffering from a hypoxic condition and methods utilizing the device to protect the patients from reperfusion injury upon restoration of oxygenated blood to a hypoxic tissue.Type: GrantFiled: May 18, 2018Date of Patent: April 9, 2024Assignees: University of Cincinnati, Children's Hospital Medical CenterInventors: Kevin Haworth, Christy K. Holland, Karla Mercado-Shekhar, Andrew Redington, Bryan H. Goldstein
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Publication number: 20200306178Abstract: Methods and compositions for treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient are provided. The method comprises administering a composition comprising a perfluorocarbon droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.Type: ApplicationFiled: May 7, 2020Publication date: October 1, 2020Inventors: Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth
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Patent number: 10688039Abstract: Methods and compositions for treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient are provided. The method comprises administering a composition comprising a perfluorocarbon droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.Type: GrantFiled: August 26, 2016Date of Patent: June 23, 2020Assignee: University of CincinnatiInventors: Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth
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Publication number: 20200107844Abstract: Intravascular ultrasound (IVUS) catheter-based device for targeted delivery of ultrasound-activated emulsions of oxygen-scavenging droplets into the bloodstream of patients suffering from a hypoxic condition and methods utilizing the device to protect the patient from reperfusion injury upon restoration of oxygenated blood to the hypoxic tissue.Type: ApplicationFiled: May 18, 2018Publication date: April 9, 2020Inventors: Kevin Haworth, Christy K. Holland, Karla Mercado-Shekhar, Andrew Redington, Bryan H. Goldstein
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Patent number: 10357448Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.Type: GrantFiled: October 10, 2017Date of Patent: July 23, 2019Assignee: Board of Regents, The University of Texas SystemInventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
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Publication number: 20180303750Abstract: Methods and compositions for treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient are provided. The method comprises administering a composition comprising a perfluorocarbon droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.Type: ApplicationFiled: August 26, 2016Publication date: October 25, 2018Inventors: Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth
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Publication number: 20180042841Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.Type: ApplicationFiled: October 10, 2017Publication date: February 15, 2018Applicants: Board of Regents, The University of Texas System, Univeristy of CincinnatiInventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
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Patent number: 9814672Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.Type: GrantFiled: March 7, 2008Date of Patent: November 14, 2017Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
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Patent number: 9675820Abstract: Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.Type: GrantFiled: January 28, 2016Date of Patent: June 13, 2017Assignee: University of CincinnatiInventors: Christy K. Holland, Saurabh Datta, T. Douglas Mast, Nikolas Ivancevich, Kathryn Elizabeth Hitchcock, Kevin Haworth
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Patent number: 9669203Abstract: Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include administering vesicles having a nucleating agent and a therapeutic drug to a vascular system of a patient, and providing an active interval of ultrasonic exposure substantially throughout a targeted treatment zone. The ultrasonic exposure is produced by a source transducer at a specified fundamental frequency, amplitude, duty cycle, and duration. The methods also include detecting a scattered ultrasonic wave, where the scattered ultrasonic wave is received by a detection transducer. Detection of the scattered ultrasonic wave is indicative of stable and/or inertial cavitation. The ultrasonic exposure is provided intermittently in the active intervals separated by rest periods, and substantially less ultrasonic exposure is provided during the rest period than during the active interval.Type: GrantFiled: March 1, 2012Date of Patent: June 6, 2017Assignee: University of CincinnatiInventors: Christy K. Holland, Kathryn E. Hitchcock, Kevin Haworth, Nikolas Ivancevich, T. Douglas Mast
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Publication number: 20160144203Abstract: Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.Type: ApplicationFiled: January 28, 2016Publication date: May 26, 2016Inventors: Christy K. Holland, Saurabh Datta, T. Douglas Mast, Nikolas Ivancevich, Kathryn Elizabeth Hitchcock, Kevin Haworth
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Publication number: 20120271167Abstract: Methods and systems for inducing and passively detecting stable cavitation and/or inertial cavitation for targeted drug delivery across a biological membrane are disclosed. Such methods include administering vesicles having a nucleating agent and a therapeutic drug to a vascular system of a patient, and providing an active interval of ultrasonic exposure substantially throughout a targeted treatment zone. The ultrasonic exposure is produced by a source transducer at a specified fundamental frequency, amplitude, duty cycle, and duration. The methods also include detecting a scattered ultrasonic wave, where the scattered ultrasonic wave is received by a detection transducer. Detection of the scattered ultrasonic wave is indicative of stable and/or inertial cavitation. The ultrasonic exposure is provided intermittently in the active intervals separated by rest periods, and substantially less ultrasonic exposure is provided during the rest period than during the active interval.Type: ApplicationFiled: March 1, 2012Publication date: October 25, 2012Applicant: UNIVERSITY OF CINCINNATIInventors: Christy K. Holland, Kathryn E. Hitchcock, Kevin Haworth, Nikolas Ivancevich, T. Douglas Mast
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Publication number: 20120130288Abstract: Methods and systems for passively detecting stable cavitation and enhancing stable cavitation during sonothrombolysis are provided. The method of passively detecting stable cavitation includes providing a determined level of ultrasonic energy and detecting a scattered level of ultrasonic energy. The system for inducing and passively detecting stable cavitation includes a dual-element annular transducer array configured to provide a fundamental ultrasonic frequency and to detect an ultrasonic frequency that is a derivative of the fundamental frequency. The method of enhancing stable cavitation includes administering a nucleating agent and a thrombolytic agent to a treatment zone, providing a determined level of ultrasonic energy, and detecting a scattered level of ultrasonic energy.Type: ApplicationFiled: March 19, 2010Publication date: May 24, 2012Applicant: University of CincinnatiInventors: Christy K. Holland, Saurabh Datta, T. Douglas Mast, Nikolas Ivancevich, Kathryn Elizabeth Hitchcock, Kevin Haworth
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Publication number: 20080305156Abstract: We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.Type: ApplicationFiled: March 7, 2008Publication date: December 11, 2008Inventors: Susan T. Laing, Shaoling Huang, David D. McPherson, Christy K. Holland, Melvin E. Klegerman
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Patent number: 7300414Abstract: A method of transcranial ultrasound thrombolysis comprises the steps of providing a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing the M1 branch and M2 branches of the middle cerebral artery of an individual. A thrombolytic agent is also administered to the individual. A transcranial ultrasound thrombolysis system (10) is also provided that includes a transducer (20). The transducer is adapted to provide a predetermined level of ultrasonic energy substantially throughout a primary treatment zone encompassing at least a substantial portion of the M1 branch and the M2 branches of the middle cerebral artery in one hemisphere of a brain.Type: GrantFiled: November 1, 2000Date of Patent: November 27, 2007Assignee: University of CincinnatiInventors: Christy K. Holland, Daniel S. Kanter, Lawrence J. Busse, Kenneth R. Wagner