Abstract: An apparatus and method for moiety specific sample extraction from a complex sample matrix in a flow through process is provided. The present invention relates to an integrated membrane for separation and preservation of biomolecules. Classes of biomolecules, for example, those in blood, can be separated and preserved. For blood separation, the apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity thereof. The housing also includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting substantially all cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion.

Abstract: An apparatus and method for moiety specific sample extraction from a complex sample matrix in a flow through process is provided. The present invention relates to an integrated membrane for separation and preservation of biomolecules. Classes of biomolecules, for example, those in blood, can be separated and preserved. For blood separation, the apparatus includes a housing having a matrix portion, and a fluid collection portion disposed within an inner cavity thereof. The housing also includes an aperture permitting access to the inner cavity. The apparatus also includes a matrix disposed within the matrix portion. The matrix includes a first layer for collecting substantially all cells from the fluid, a second layer for protein adsorption, and a third layer for nucleic acid adsorption. Fluid enters the housing through the aperture, passes through the matrix, and into the fluid collection portion.

Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.