Patents by Inventor Chron-Si Lai

Chron-Si Lai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10328049
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Patent number: 10245250
    Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 2, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Matthew Kuchan, Chron-Si Lai, Jacqueline Boff
  • Publication number: 20190014807
    Abstract: Disclosed embodiments provide nutritional compositions and methods of enhancing maturation of an infant's brain. The methods include the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75% in combination with at least one of a monoglyceride, a free fatty acid, a salt of a free fatty acid, a phospholipid, and cholesterol.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 17, 2019
    Applicant: ABBOTT LABORATORIES
    Inventors: TAPAS DAS, MUSTAFA VURMA, CHRON-SI LAI, PAUL JOHNS
  • Publication number: 20190000913
    Abstract: Disclosed embodiments provide a method of enhancing maturation of a lung, brain, or both, in an infant. The method includes the step of administering to the infant a nutritional composition comprising a protein with a degree of hydrolysis of 10% to 75%. Also disclosed are methods for reducing the incidence of necrotizing enterocolitis in an individual. In addition, the disclosed embodiments provide a method for the prevention, delay of progression, or the treatment of a circulatory disorder characterized by inadequate blood flow to the brain or lung.
    Type: Application
    Filed: December 27, 2016
    Publication date: January 3, 2019
    Applicant: ABBOTT LABORATORIES
    Inventors: TAPAS DAS, MUSTAFA VURMA, CHRON-SI LAI, PAUL JOHNS
  • Publication number: 20180256536
    Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Applicant: ABBOTT LABORATORIES
    Inventors: MATTHEW KUCHAN, CHRON-SI LAI, JACQUELINE BOFF
  • Publication number: 20180235930
    Abstract: Disclosed are methods of using nutritional compositions generally, and infant formulas specifically, to improve cognitive, brain and/or central nervous system development in an individual. The nutritional compositions include a combination of RRR-alpha tocopherol acetate, non-RRR-alpha-tocopherol stereoisomers, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited.
    Type: Application
    Filed: April 25, 2018
    Publication date: August 23, 2018
    Applicant: ABBOTT LABORATORIES
    Inventors: CHRON-SI LAI, MATTHEW KUCHAN
  • Patent number: 9993457
    Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: June 12, 2018
    Assignee: Abbott Laboratories
    Inventors: Matthew Kuchan, Chron-Si Lai, Jacqueline Boff
  • Patent number: 9980939
    Abstract: Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited. Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 29, 2018
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan
  • Publication number: 20180085343
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 29, 2018
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Patent number: 9844517
    Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: December 19, 2017
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, John B. Lasekan, Gary E. Katz, Christopher T. Cordle
  • Patent number: 9844532
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 19, 2017
    Assignee: Abbott Laboratories
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Publication number: 20170258759
    Abstract: Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant are also disclosed. Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are disclosed. Methods for improving the visual acuity of a healthy infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed. Methods for improving the development of the visual processing, visual acuity, or both, of an infant by administering a composition comprising RRR-alpha-tocopherol to the infant are also disclosed.
    Type: Application
    Filed: November 25, 2015
    Publication date: September 14, 2017
    Applicant: ABBOTT LABORATORIES
    Inventors: MATTHEW KUCHAN, CHRON-SI LAI, JACQUELINE BOFF
  • Publication number: 20160279095
    Abstract: Disclosed herein are nutritional compositions for pregnant or lactating mothers, pre-term and term infants, toddlers and children which include natural vitamin E, a long chain polyunsaturated fatty acid (LC-PUFA) and a carotenoid such as lutein. Also disclosed are methods of administering these compositions for reducing or preventing the susceptibility of the fetal and newborn brain and lungs to hypoxia and the resulting disorders resulting therefrom including abnormal cognitive development, brain in jury and lung injury.
    Type: Application
    Filed: November 12, 2014
    Publication date: September 29, 2016
    Applicant: Abbott Laboratories
    Inventors: REMA VAZHAPPILLY, CHRON-SI LAI, MATTHEW KUCHAN
  • Patent number: 9446005
    Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: September 20, 2016
    Assignee: Abbott Laboratories
    Inventors: Chron-Si Lai, Keith A. Garleb, John B. Lasekan, Steven R. Davis, Christopher T. Cordle, Russell J. Merritt
  • Patent number: 9433586
    Abstract: Disclosed are nutritional formulations including predigested fats that can be administered to preterm infants, infants, toddlers, and children for improving tolerance, digestion, and absorption of nutrients and for reducing the incidence of necrotizing enterocolitis, colic, and short bowel syndrome. The predigested fats include fatty acid-containing monoglycerides and/or a fatty acid component.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: September 6, 2016
    Assignee: Abbott Laboratories
    Inventors: Chron-Si Lai, Steven Davis, Keith Garleb, John Lasekan
  • Publication number: 20160029681
    Abstract: A method of enhancing the bioavailability of a lipid-soluble nutrient, such as DHA, arachidonic acid, tocopherol, and carotenoids, in a newborn or preterm infant is disclosed. In this method, the lipid-soluble nutrient is administered in a nutritional product (such as an infant formula) to a preterm or newborn infant. The nutritional product comprises (a) an effective amount of the lipid-soluble nutrient; and (b) a fatty component comprising a combination of: (i) at least 6 g/l predigested fat, wherein the predigested fat includes at least one of: monoglycerides, free fatty acids, or a combination of monoglycerides and free fatty acids, and (ii) at least 1.44 g/l phospholipid. A method of enhancing cognition in newborn or preterm infants utilizing the nutritional product is also disclosed.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Randal Buddington, John Lasekan
  • Publication number: 20160021919
    Abstract: A method of enhancing maturation of a lung, gut, or both in an infant. The method includes the step of administering to the infant a nutritional composition including from about 3 weight % phospholipids to about 20 weight % phospholipids, based on total fat of the nutritional composition.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Randal Buddington
  • Publication number: 20160022628
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Publication number: 20160022710
    Abstract: Disclosed are prenatal and lactation supplements for pregnant women and lactating women, which include a combination of RRR-alpha-tocopherol, docosahexaenoic acid (DHA), trans-lutein, phospholipids, and at least one nuclear receptor activating ligand other than RRR-alpha-tocopherol, DHA, and trans-lutein. The supplements may enhance central nervous system development in a fetus or breast-feeding newborn infant.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 28, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Tama Bloch, Christina Sherry, Maria Ramirez Gonzalez, Matthew Kuchan, Gary Katz, Elena Oliveros Delgado, Angela Santos
  • Publication number: 20160008318
    Abstract: Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The amount of non-RRR alpha tocopherol stereoisomers in the nutritional compositions is limited Also disclosed are methods of using the compositions to improve cognitive, brain and/or central nervous system development in an individual.
    Type: Application
    Filed: March 13, 2014
    Publication date: January 14, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan