Patents by Inventor Chrystal Paulos

Chrystal Paulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ICOS CRITICALLY REGULATES THE EXPANSION AND FUNCTION OF INFLAMMATORY HUMAN TH17 CELLS
    Publication number: 20230399615
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Application
    Filed: March 3, 2023
    Publication date: December 14, 2023
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • ICOS critically regulates the expansion and function of inflammatory human Th17 cells
    Patent number: 11001805
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 11, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells
    Publication number: 20180371414
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Application
    Filed: May 22, 2018
    Publication date: December 27, 2018
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • ICOS critically regulates the expansion and function of inflammatory human Th17 cells
    Patent number: 9994818
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: June 12, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells
    Publication number: 20150342994
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 3, 2015
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • ICOS critically regulates the expansion and function of inflammatory human Th17 cells
    Patent number: 9133436
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: September 15, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce Levine
  • ICOS Critically Regulates the Expansion and Function of Inflammatory Human Th17 Cells
    Publication number: 20130071409
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Application
    Filed: February 4, 2011
    Publication date: March 21, 2013
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce Levine