Abstract: Provided is a bifunctional compound, or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein the bifunctional compound is represented by Formula (I): ABM-L-CLM??(I); wherein: ABM is an androgen receptor binding moiety; -L- is a linking moiety; and CLM is a cereblon E3 ubiquitin ligase binding moiety represented by Formula (II)-1: wherein one end of the -L- is covalently joined to Q3, Q4, Q5 or Q6; and the other end of the -L- is covalently joined to the ABM. Also provided are a pharmaceutical composition comprising the bifunctional compound and a method for treating an androgen receptor related disease or disorder by administering the bifunctional compound.

Abstract: This disclosure relates to cereblon E3 ubiquitin ligase binding compositions comprising one or more of the cereblon E3 ubiquitin ligase binding compositions, and to methods of use the cereblon E3 ubiquitin ligase binding compositions for the degrading target proteins associated with a disease or condition.

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the degrading target proteins associated with a disease or condition.

Abstract: A three-dimensional sensing panel includes a cover plate, a two-dimensional touch sensing module, a pressure sensing coating layer, and a light-transmitting electrode layer. The cover plate defines thereon a touch area and a peripheral area surrounding the touch area. The two-dimensional touch sensing module is disposed at the touch area. The pressure sensing coating layer is coated at a side of the two-dimensional touch sensing module away from the cover plate. The light-transmitting electrode layer is coated at a side of the pressure sensing coating layer away from the two-dimensional touch sensing module.

Abstract: A three-dimensional sensing panel includes a cover plate, a two-dimensional touch sensing module, a pressure sensing coating layer, and a light-transmitting electrode layer. The cover plate defines thereon a touch area and a peripheral area surrounding the touch area. The two-dimensional touch sensing module is disposed at the touch area. The pressure sensing coating layer is coated at a side of the two-dimensional touch sensing module away from the cover plate. The light-transmitting electrode layer is coated at a side of the pressure sensing coating layer away from the two-dimensional touch sensing module.

Abstract: An electronic apparatus includes a flexible cover plate, a force sensing module, a touch display module, and a metal thin plate. The force sensing module includes a flexible electrode and a flexible force-sensitive composite layer. The flexible force-sensitive composite layer includes at least one flexible electrode layer and at least one functional spacer layer. The flexible electrode layer has a first resistivity. The functional spacer layer has a second resistivity greater than the first resistivity. The flexible electrode layer and the functional spacer layer are disposed under the flexible electrode. The touch display module is disposed between the flexible cover plate and the force sensing module and includes an organic light emitting display unit and a touch sensing layer. The metal thin plate is disposed under the force sensing module and serves as a contact electrode of the force sensing module.

Abstract: The present invention provides a system and method of wireless transmission in GPRS communications network, comprising a virtual COM utility program for creating virtual COM ports. A GPRS virtual COM gateway server is coupled to the virtual COM ports via LAN or Internet. A plurality of remote electronic device is coupled to its corresponding GPRS data terminals. Remote electronic devices can connect to GPRS virtual COM gateway server by GPRS data terminals through GPRS network and Internet for wireless transmitting data to the local device.