Patents by Inventor Chu-Chih Shih

Chu-Chih Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification and characterization of cancer stem cells and methods of use
    Patent number: 8569055
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: October 29, 2013
    Assignee: City of Hope
    Inventors: Margarita Gutova, Chu-Chih Shih, Anna Gevorgyan, Karen Aboody, Josip Najbauer
  • IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS AND METHODS OF USE
    Publication number: 20110003386
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Application
    Filed: April 27, 2010
    Publication date: January 6, 2011
    Inventors: Margarita GUTOVA, Chu-Chih Shih, Anna Gevorgyan, Karen Aboody, Josip Najbauer
  • Method of using protease inhibitors for the treatment of liposarcomas
    Patent number: 7812034
    Abstract: Liposarcomas are treated using HIV protease inhibitors, particularly nelfinavir. The protease inhibitors may be used alone or in combination with traditional cancer treatments, such as chemotherapy, radiotherapy, or surgery.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: October 12, 2010
    Assignee: City of Hope
    Inventors: Warren Chow, Chu-Chih Shih
  • IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS AND METHODS OF USE
    Publication number: 20070244046
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 18, 2007
    Inventors: Margarita Gutova, Chu-Chih Shih, Anna Gevorgyan, Aboody Karen, Najbauer Josip
  • Method of using protease inhibitors for the treatment of liposarcomas
    Publication number: 20050176658
    Abstract: Liposarcomas are treated using HIV protease inhibitors, particularly nelfinavir. The protease inhibitors may be used alone or in combination with traditional cancer treatments, such as chemotherapy, radiotherapy, or surgery.
    Type: Application
    Filed: November 2, 2004
    Publication date: August 11, 2005
    Inventors: Warren Chow, Chu-Chih Shih
  • Ex vivo expansion of mammalian hematopoietic stem cells
    Publication number: 20020160512
    Abstract: A method for the ex-vivo expansion of mammalian hematopoietic stem cells (HSC) comprises culturing isolated HSC in a culture system comprising a culture medium in the presence of a stem cell expansion promoting factor (SCEPF) which may be obtained by culturing murine stromal cells in the presence of an amount of leukemia inhibitory factor (LIF) sufficient to stimulate the production and secretion of said expansion promoting factor.
    Type: Application
    Filed: April 30, 2002
    Publication date: October 31, 2002
    Inventor: Chu-Chih Shih