Abstract: A thrombus removal device (100) comprising a catheter (10), at least one valve (20), and a shaft (30) is provided. The catheter (10) has a proximal end (12) and a distal end (11), and defines a longitudinal axis. The at least one valve (20) is positioned and movable longitudinally inside the catheter (10). The shaft (30) is connected with the proximal end (12) of the catheter (10), and comprises a driving mechanism and a wire (34). Wherein, the wire (34) is connected to the driving mechanism at one end and connected to the at least one valve (20) at an opposite end. The driving mechanism is configured to create a sudden movement of the at least one valve (20) toward the proximal end (12) of the catheter (10). By using the thrombus removal device (100), thrombus can be removed from the body of a subject more efficiently.