Abstract: A multi-axis machine tool includes a housing composed of interconnected housing wall panels, and a slide guide member disposed inside and fixed to the housing wall panels. A first slide has a first frame composed of interconnected first wall panels and slidable on the slide guide member to move along a first axis. A second slide has a second frame slidable on a first guide member disposed inside and fixed to the first wall panels and movable along a second axis perpendicular to the first axis. A tool operator is mounted on the second frame, and a workpiece holder is mounted to the housing proximate to the tool operator. The machine tool has a simple high precision structure.