Patents by Inventor Chuan Shih

Chuan Shih has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060223871
    Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
    Type: Application
    Filed: June 6, 2006
    Publication date: October 5, 2006
    Inventors: Cora Grossman, Philip Hipskind, Ho-Shen Lin, Karen Lobb, Beatriz Lopez de Uralde Garmendia, Jose Lopez, Mary Mader, Michael Richett, Chuan Shih, Alfonso De Dios
  • Patent number: 7084170
    Abstract: The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: August 1, 2006
    Assignee: Eli Lilly and Company
    Inventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso De Dios
  • Patent number: 6975459
    Abstract: A volume diffractive composite is disclosed for providing illumination at a first output angle. The volume diffractive composite comprises a first plurality of grating elements that are mutually spaced from another in a first position with a first spacing period along a first plane, and an actuation unit for changing at least one of the position or the spacing period of the first plurality of grating elements to a second position or spacing period to provide illumination at a second output angle.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: December 13, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: George Barbastathis, Sang-Gook Kim, Wei-Chuan Shih, Chee Wei Wong, Yong-Bae Jeon
  • Publication number: 20050100977
    Abstract: The invention is a biochemical sensing device, including a photodiode capable of sensing the light generated by the reaction made by a specific compound, a specific enzyme, and a luminol as well as converting the optical signal into a current signal. Also, there is a current/voltage converting circuit capable of converting the current signal into an analog voltage signal. In turn, the analog voltage signal can be converted into a digital voltage signal through an analog/digital converter. Finally, by using an electronic device, the digital voltage signal can be received and analyzed, and through the analysis, the amount of the specific compound can be measured. The device of the invention can provide a simple real-time medical assay that can be performed in massive amount. For this reason, the drawbacks of a conventional spectrum analysis instrument of being bulky and expensive can be improved.
    Type: Application
    Filed: February 6, 2004
    Publication date: May 12, 2005
    Inventors: Yuh-Shyong Yang, Chung-Yu Wu, Ude Lu, Yu-Chuan Shih, Ben Hu
  • Patent number: 6867198
    Abstract: The present invention provides selective kinase inhibitors of formula (I)
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: March 15, 2005
    Assignee: Eli Lilly and Company
    Inventors: Rima Salim Al-Awar, Kyle Andrew Hecker, James Edward Ray, Jianping Huang, Sajan Joseph, Tiechao Li, Michael Paal, Radhakrishnan Rathnachalam, Chuan Shih, Philip Parker Waid, Xun Zhou, Guoxin Zhu
  • Publication number: 20040198784
    Abstract: The present invention provides antineoplastic compounds of the formula (D).
    Type: Application
    Filed: March 26, 2004
    Publication date: October 7, 2004
    Inventors: Cora Sue Grossman, Philip Arthur Hipskind, Ho-Shen Lin, Karen Lynn Lobb, Beatriz Lopez de Uralde Garmendia, Jose Eduardo Lopez, Mary Margaret Mader, Michael Enrico Richett, Chuan Shih, Alfonso de Dios
  • Publication number: 20040179268
    Abstract: A volume diffractive composite is disclosed for providing illumination at a first output angle. The volume diffractive composite comprises a first plurality of grating elements that are mutually spaced from another in a first position with a first spacing period along a first plane, and an actuation unit for changing at least one of the position or the spacing period of the first plurality of grating elements to a second position or spacing period to provide illumination at a second output angle.
    Type: Application
    Filed: March 12, 2003
    Publication date: September 16, 2004
    Inventors: George Barbastathis, Sang-Gook Kim, Wei-Chuan Shih, Chee Wei Wong, Yong-Bae Jeon
  • Publication number: 20040157741
    Abstract: The present invention provides antitumor compounds of the formula (I), and antitumor methods.
    Type: Application
    Filed: November 18, 2003
    Publication date: August 12, 2004
    Inventors: Chuan Shih, Cora Grossman, Karen Lobb, Thomas Hughes Corbett, Ho-Shen Lin
  • Patent number: 6680311
    Abstract: The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: January 20, 2004
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: Rima S Al-Awar, William J Ehlhardt, Subbaraju V Gottumukkala, Michael J Martinelli, Eric D Moher, Richard E Moore, John E Munroe, Bryan H Norman, Vinod F Patel, James E Ray, Chuan Shih, John E Toth, Venkatraghavan Vasudevan
  • Publication number: 20030229026
    Abstract: The present invention provides selective kinase inhibitors of formula (I).
    Type: Application
    Filed: December 2, 2002
    Publication date: December 11, 2003
    Inventors: Rima Salim Al-Awar, Kyle Andrew Hecker, James Edward Ray, Jianping Huang, Sajan Joseph, Tiechao Li, Michael Paal, Radhakrishnan Rathnachalam, Chuan Shih, Philip Parker Waid, Xun Zhou, Guoxin Zhu
  • Publication number: 20030173751
    Abstract: A shoe and a wheel device include one end detachably secured together with a projection-and-lock notch engagement. A toe member and a heel member are engaged on the front and the rear portions of the shoe. The wheel device includes one or more projections extended from the front portion for detachably securing to the toe member without additional fasteners or tools. One or more latches are attached to the rear portion of the wheel device for latching and securing the heel member and the rear portion of the shoe to the wheel device without additional fasteners or tools.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 18, 2003
    Inventor: Fang Chuan Shih
  • Patent number: 6572121
    Abstract: A shoe and a wheel device include one end detachably secured together with a projection-and-lock notch engagement. A toe member and a separate heel member are engaged on the front and the rear portions of the shoe. A latch is attached to the wheel device for latching and securing the heel member and the rear portion of the shoe to the wheel device. A quick release lock device is attached to the middle portion of the wheel device and engageable with the heel member for locking the heel member and the middle portion of the shoe to the wheel device.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: June 3, 2003
    Inventor: Fang Chuan Shih
  • Publication number: 20030062696
    Abstract: A shoe and a wheel device include one end detachably secured together with a projection-and-lock notch engagement. A toe member and a heel member are engaged on the front and the rear portions of the shoe. A latch is attached to the wheel device for latching and securing the heel member and the rear portion of the shoe to the wheel device. A quick release lock device is attached to the middle portion of the wheel device and engageable with the heel member for locking the heel member and the middle portion of the shoe to the wheel device.
    Type: Application
    Filed: September 28, 2001
    Publication date: April 3, 2003
    Inventor: Fang Chuan Shih
  • Publication number: 20030031868
    Abstract: A corona-resistant self-lubricating magnet wire includes a conductor wire, an insulator sheath wrapped around the conductor wire, and an outer layer of a lubricating material coated on the sheath. The lubricating material is composed of a polyamideimide resin and a polymeric material selected from a group consisting of polyethylene and Teflon.
    Type: Application
    Filed: August 27, 2001
    Publication date: February 13, 2003
    Applicant: Pacific Electric Wire & Cable Co., Ltd.
    Inventors: Ching-Rong Shue, Shin-Chuan Shih, Jen-Wen Cheng
  • Publication number: 20020128185
    Abstract: The invention provides novel cryptophycin compounds which can be useful for disrupting the microtubulin system, as antineoplastic agents, antifungal, and for the treatment of cancer. The invention further provides a formulation for administering the novel cryptophycin compounds.
    Type: Application
    Filed: November 16, 2001
    Publication date: September 12, 2002
    Inventor: Chuan Shih
  • Patent number: 6200090
    Abstract: An pump casing for a sheet metal pump includes a pump body made by pressing or roll forming a sheet metal, a reinforced member which includes a water guide unit and a flange unit separately made by casting or CNC machining and a seal ring engaged with the water guide unit. The pump body is a simple basin shape which can be produced with less stress concentration. The water guide unit may be made with a more precise volute for achieving better pumping efficiency. The reinforced member may increase structural strength of the pump casing for withstanding greater pumping pressure and external forces. The seal ring may be positioned precisely without dislocation because it engages with the water guide unit rather than the pump casing. The gap between the seal ring and the impeller may be kept small and constant, thus obtaining better pumping efficiency, lower operation noise and greater durability.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: March 13, 2001
    Assignee: Industrial Technology Research Institute
    Inventors: Huan-Jan Chien, Kuo-Yu Tang, Ming-Chuan Shih, Charlie Pen
  • Patent number: 6180679
    Abstract: The present invention provides a method for controlling fungal growth, mycotic infections, yeast infections and parasitic infections using a therapeutically effective amount of a compound selected from Compounds (I-V). Further provided is a method for providing mdr inhibition using a therapeutically effective amount of a compound of formula (IA). Also provided is an antifungal composition comprising at least five percent (5%) by weight of a compound selected from Compounds (I-V).
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: January 30, 2001
    Assignee: Eli Lilly and Company
    Inventors: Chuan Shih, Daniel Charles Williams
  • Patent number: 6066639
    Abstract: Glutamic acid derivatives in which the amino group is substituted with a 2-amino-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-ylalkyl-Z-carbonyl group, in which Z is a divalent, five-membered, nitrogen-containing heterocyclic ring system optionally containing a sulfur or nitrogen atom as a second hetero ring member, are antineoplastic agents. A typical embodiment is N-{3-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)e thyl]-pyrazol-5-ylcarbonyl}-L-glutamic acid.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: May 23, 2000
    Assignees: The Trustees of Princeton University, Eli Lilly and Company
    Inventors: Edward C. Taylor, Chuan Shih, Koo Lee, Lynn S. Gossett
  • Patent number: 5786358
    Abstract: 2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido?2,3-d!pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-{4-?2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido?2,3-d!pyrimidin-6-y l)ethyl!benzoyl}-L-.gamma.-glutamyl)-D-aspartic acid.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: July 28, 1998
    Assignee: The Trustees of Princeton University
    Inventors: Chuan Shih, Lynn S. Gossett, William J. Gill, Edward C. Taylor, James T. Metz
  • Patent number: 5426110
    Abstract: The present invention provides novel pyrimidinyl-glutamic acid derivatives and intermediates thereto. Further provided are methods for inhibiting dihydrofolate reductase in mammals and for treating susceptible neoplasms in mammals, particularly humans.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: June 20, 1995
    Assignee: Eli Lilly and Company
    Inventors: Lynn S. Gossett, Chuan Shih