Abstract: Embodiments of the present disclosure provide systems and methods for brain identifier localization. The methods include obtaining an image of a brain; determining region identifier probability map(s) of the brain, landmark identifier probability map(s) of the brain, and plane identifier probability map(s) of the brain based on the image and a neural network model; determining a segmentation result of a cerebral cortex of the brain, landmark identifier(s) of the brain, and plane identifier(s) of the brain, respectively, based on the region identifier probability map(s), the landmark identifier probability map(s), and the plane identifier probability map(s); constructing a target coordinate system based on the landmark identifier(s) and the plane identifier(s); and determining landmark(s) of the cerebral cortex based on the segmentation result of the cerebral cortex, the target coordinate system, and/or the landmark identifier(s).