Patents by Inventor Chuanbin Mao
Chuanbin Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11839642Abstract: Carrier compositions, including human-safe phages, equipped with one or more angiogenin-binding peptides, and optionally with tumor-homing peptides for use in anti-tumor therapies, are described. The angiogenin-binding peptides bind to and inactivate angiogenin molecules thereby blocking their angiogenic activity thus inhibiting angiogenesis in the tissue in which the compositions are localized.Type: GrantFiled: April 9, 2019Date of Patent: December 12, 2023Assignee: The Board of Regents of the University of OklahomaInventors: Chuanbin Mao, Yan Li
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Patent number: 11634507Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.Type: GrantFiled: April 2, 2020Date of Patent: April 25, 2023Assignee: The Board of Regents of the University of OklahomaInventors: Chuanbin Mao, Lin Wang, Penghe Qiu
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Patent number: 11261427Abstract: A bacteriophage structure, a method of making the structure, and uses of the structure are described. The structure is a substrate with a surface having an ordered arrangement of parallel microridges thereon. Each microridge is composed of a plurality of nanoridges and has a longitudinal axis. Each nanoridge contains a bundle of phage nano fibers having longitudinal axes. The phage nanofibers in each nanoridge bundle are arranged in a substantially smectic alignment. The longitudinal axis of each microridge is perpendicular to the longitudinal axes of the phage nanofibers which make up the nanoridges of the microridge. The structure may be used as a growth surface for inducing differentiation of stem cells such as neural progenitor cells.Type: GrantFiled: April 10, 2020Date of Patent: March 1, 2022Assignee: The Board of Regents of the University of OklahomaInventors: Chuanbin Mao, Ningyun Zhou
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Publication number: 20220049218Abstract: A bacteriophage structure, a method of making the structure, and uses of the structure are described. The structure is a substrate with a surface having an ordered arrangement of parallel microridges thereon. Each microridge is composed of a plurality of nanoridges and has a longitudinal axis. Each nanoridge contains a bundle of phage nano fibers having longitudinal axes. The phage nanofibers in each nanoridge bundle are arranged in a substantially smectic alignment. The longitudinal axis of each microridge is perpendicular to the longitudinal axes of the phage nanofibers which make up the nanoridges of the microridge. The structure may be used as a growth surface for inducing differentiation of stem cells such as neural progenitor cells.Type: ApplicationFiled: April 10, 2020Publication date: February 17, 2022Inventors: Chuanbin Mao, Ningyun Zhou
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Publication number: 20210369812Abstract: Osteoinductive, bone morphogenic protein receptor-binding peptides are disclosed. The peptides may be used to coat or infuse scaffolds for use as implants into bone for enhancing the growth, proliferation, and differentiation of mesenchymal stem cells and/or osteoblasts in the bone.Type: ApplicationFiled: April 9, 2019Publication date: December 2, 2021Inventors: Chuanbin Mao, Kegan Sunderland
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Publication number: 20210189012Abstract: A method of producing dendritic gold nanoparticles by combining a gold precursor solution, a reducing agent, and a bifunctional peptide having an amine-rich amino acid sequence into a buffered aqueous solution in a single container, and agitating the mixture causing the formation of the dendritic gold nanoparticles having a surface with a positive charge and a second end portion of the bifunctional peptide exposed on the surface of the dendritic gold nanoparticles. The dendritic gold nanoparticles may be used to deliver therapeutic, diagnostic, and/or immunogenic amino acid sequences as portions of the bifunctional peptide.Type: ApplicationFiled: April 2, 2020Publication date: June 24, 2021Inventors: Chuanbin Mao, Lin Wang, Penghe Qiu
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Publication number: 20200384066Abstract: Carrier compositions, including human-safe phages, equipped with one or more angiogenin-binding peptides, and optionally with tumor-homing peptides for use in anti-tumor therapies, are described. The angiogenin-binding peptides bind to and inactivate angiogenin molecules thereby blocking their angiogenic activity thus inhibiting angiogenesis in the tissue in which the compositions are localized.Type: ApplicationFiled: April 9, 2019Publication date: December 10, 2020Inventors: CHUANBIN MAO, Yan Li
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Publication number: 20200318168Abstract: Oligonucleotide probes and kits containing same are disclosed, along with methods of use thereof. The oligonucleotide probe comprises a nucleic acid probe sequence comprising a hairpin loop and having a reporter moiety linked to a first end thereof and a quencher moiety linked to a second end thereof. In certain embodiments, the reporter moiety is an upconversion nanoparticle, and the quencher moiety is a gold nanoparticle. The quencher moiety quenches the reporter moiety when the nucleic acid probe sequence is not bound to a complementary target nucleic acid sequence, and the reporter moiety becomes unquenched when the nucleic acid probe sequence binds to a complementary target nucleic acid sequence.Type: ApplicationFiled: April 2, 2020Publication date: October 8, 2020Inventors: Chuanbin Mao, Yueyi Sun
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Patent number: 10073109Abstract: Disclosed are genetically-modified phages, comprising a first nucleic acid sequence encoding at least a first peptide able to bind to a magnetic nanoparticle, and a second nucleic acid sequence encoding at least a second peptide able to bind with high specificity to a predetermined biomarker, and a method for using the genetically-modified phage displaying the first peptide and second peptide in a method for analyzing a fluid sample for the predetermined biomarker.Type: GrantFiled: April 5, 2016Date of Patent: September 11, 2018Assignee: The Board of Regents of the University of OklahomaInventors: Chuanbin Mao, Binrui Cao
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Publication number: 20180203026Abstract: Disclosed are genetically-modified phages, comprising a first nucleic acid sequence encoding at least a first peptide able to bind to a magnetic nanoparticle, and a second nucleic acid sequence encoding at least a second peptide able to bind with high specificity to a predetermined biomarker, and a method for using the genetically-modified phage displaying the first peptide and second peptide in a method for analyzing a fluid sample for the predetermined biomarker.Type: ApplicationFiled: April 5, 2016Publication date: July 19, 2018Inventors: Chuanbin Mao, Binrui Cao
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Publication number: 20180009036Abstract: Methods of synthesizing gold nanodendrites (AuNDs) using amines, such as long chain amines, as a structural directing agent are disclosed. Degree of branching (DB) of the AuNDs can be tuned by adjusting certain synthetic parameters, such as solvent type, and the type and concentration of the long chain amines. DB control results in dramatic tunability of the optical properties of the AuNDs in the near infrared (NIR) range enabling improved performance, for example as a photothermal cancer therapeutic.Type: ApplicationFiled: June 28, 2017Publication date: January 11, 2018Inventors: Chuanbin Mao, Penghe Qiu
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Patent number: 8969252Abstract: The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.Type: GrantFiled: April 7, 2011Date of Patent: March 3, 2015Assignee: Board of Regents, University of Texas SystemInventors: Angela M. Belcher, Brian D. Reiss, Chuanbin Mao, Daniel J. Solis
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Patent number: 8846190Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: GrantFiled: August 27, 2013Date of Patent: September 30, 2014Assignees: The Board of Regents, The University of Texas System, Massachusetts Institute of TechnologyInventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Publication number: 20140212664Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: ApplicationFiled: August 27, 2013Publication date: July 31, 2014Applicants: Massachusetts Institute of Technology, Board of Regents, The University of Texas SystemInventors: Angela M. BELCHER, Chuanbin MAO, Daniel J. SOLIS
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Patent number: 8709892Abstract: A method for fabricating a flash memory device where the flash memory device includes a substantially uniform size and spatial distribution of nanoparticles on a tunnel oxide layer to form a floating gate. The flash memory device may be fabricated by defining active areas in a substrate and forming an oxide layer on the substrate. A self-assembled protein lattice may be formed on top of the oxide layer where the self-assembled protein lattice includes a plurality of molecular chaperones. The cavities of the chaperones may provide confined spaces where nanocrystals can be trapped thereby forming an ordered nanocrystal lattice. A substantially uniform distribution of nanocrystals may be formed on the oxide layer upon removal of the self-assembled protein lattice such as through high temperature annealing.Type: GrantFiled: May 22, 2006Date of Patent: April 29, 2014Assignee: DarpaInventors: Chuanbin Mao, Shan Tang, Sanjay Banerjee
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Patent number: 8523044Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: GrantFiled: June 18, 2012Date of Patent: September 3, 2013Assignees: Board of Regents, The University of Texas System, Massachusetts Institute of TechnologyInventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Publication number: 20120273987Abstract: Provided in one embodiment is a method of forming an inorganic nanowire, comprising: providing an elongated organic scaffold; providing a plurality of inorganic nanoparticles attached to the organic scaffold along a length of the organic scaffold; and fusing the nanoparticles attached to the organic scaffold to form an inorganic nanowire.Type: ApplicationFiled: June 18, 2012Publication date: November 1, 2012Inventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Patent number: 8201724Abstract: An inorganic nanowire having an organic scaffold substantially removed from the inorganic nanowire, the inorganic nanowire consisting essentially of fused inorganic nanoparticles substantially free of the organic scaffold, and methods of making same. For example, a virus-based scaffold for the synthesis of single crystal ZnS, CdS and free-standing L10 CoPt and FePt nanowires can be used, with the means of modifying substrate specificity through standard biological methods. Peptides can be selected through an evolutionary screening process that exhibit control of composition, size, and phase during nanoparticle nucleation have been expressed on the highly ordered filamentous capsid of the M13 bacteriophage. The incorporation of specific, nucleating peptides into the generic scaffold of the M13 coat structure can provide a viable template for the directed synthesis of a variety of materials including semiconducting and magnetic materials.Type: GrantFiled: March 4, 2011Date of Patent: June 19, 2012Assignees: Board of Regents, The University of Texas System, Massachusetts Institute of TechnologyInventors: Angela M. Belcher, Chuanbin Mao, Daniel J. Solis
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Publication number: 20110298149Abstract: An inorganic nanowire having an organic scaffold substantially removed from the inorganic nanowire, the inorganic nanowire consisting essentially of fused inorganic nanoparticles substantially free of the organic scaffold, and methods of making same. For example, a virus-based scaffold for the synthesis of single crystal ZnS, CdS and free-standing L10 CoPt and FePt nanowires can be used, with the means of modifying substrate specificity through standard biological methods. Peptides can be selected through an evolutionary screening process that exhibit control of composition, size, and phase during nanoparticle nucleation have been expressed on the highly ordered filamentous capsid of the M13 bacteriophage. The incorporation of specific, nucleating peptides into the generic scaffold of the M13 coat structure can provide a viable template for the directed synthesis of a variety of materials including semiconducting and magnetic materials.Type: ApplicationFiled: March 4, 2011Publication date: December 8, 2011Inventors: Angela M. BELCHER, Chuanbin MAO, Daniel J. SOLIS
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Publication number: 20110197711Abstract: The present invention includes methods for producing magnetic nanocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to a magnetic material.Type: ApplicationFiled: April 7, 2011Publication date: August 18, 2011Inventors: Angela M. BELCHER, Brian D. Reiss, Chuanbin Mao, Daniel J. Solis