Abstract: Substituted pyridazine phenol derivatives and a preparation method therefor, specifically relating to a compound as shown in formula (VI) and a pharmaceutically acceptable salt thereof, which can be used as an NLRP3 inhibitor.

Abstract: The present invention provides chimeric antigen receptors (CAR) and methods of use in the treatment of diseases and disorders.

Abstract: A fault detection method for a rotating machine based on sparse time synchronous averaging is disclosed, and the method includes: collecting a vibration signal and a rotating frequency or rotating frequency pulse signal of the rotating machine and performing analog-to-digital conversion to obtain the vibration signal and rotating speed information by a sensor; according to the type and number of detection components in the rotating machine, constructing a component-aware comb vector g based on the vibration signal and rotating speed information, wherein the type includes the gear, rotor and bearing; constructing a quasi-time synchronous average vector w based on the component-aware comb vector g; constructing a sparse time synchronous averaging model F by using the quasi-time synchronous average vector w; solving the sparse time synchronous averaging model F with an optimization solution algorithm to obtain a sparse spectrum and a reconstruction time signal.

Abstract: Embodiments provide a contact structure and a fabricating method. The method includes: forming an insulating dielectric layer on a substrate; forming a contact hole penetrating through the insulating dielectric layer, where the contact hole includes a first hole segment and a second hole segment communicating with each other, the first hole segment penetrates to the substrate, the second hole segment is positioned on a side of the first hole segment away from the substrate, the first hole segment has a first orthogonal projection on the substrate, the second hole segment has a second orthogonal projection on the substrate, and the second orthographic projection is positioned in the first orthographic projection; and forming a conductive plug in the contact hole.

Abstract: Related are a CSPG4-targeting humanized chimeric antigen receptor and applications thereof, comprising a humanized anti-CSPG4 binding domain, a hinge region, a transmembrane domain, and a signal transduction domain. The anti-CSPG4 binding domain comprises an anti-CSPG4 antibody or antigen binding part. Related are an immune effector cell expressing the CSPG4-targeting humanized chimeric antigen receptor and applications of the cell.

Abstract: Provided are a chimeric antigen receptor capable of targeting B7-H3, a nucleic acid molecule encoding the chimeric antigen receptor, a nucleic acid construct comprising the nucleic acid molecule, an immune effector cell expressing the chimeric antigen receptor, and use thereof. The chimeric antigen receptor comprises an anti-B7-H3 binding domain, a hinge region, a transmembrane domain and a signal transduction domain. Further provided are a composition and a method for diagnosing, treating or preventing tumors that express B7-H3.