Patents by Inventor Chuanling Zhang

Chuanling Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11923532
    Abstract: A pre-lithiated silicon-based anode includes a silicon-based anode, lithium disposed on a surface or in an interior of the silicon-based anode, and a protective coating on the surface of the silicon-based anode. The pre-lithiated silicon-based anode allows subsequent processing to be performed safely in the atmosphere.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: March 5, 2024
    Assignee: Robert Bosch GmbH
    Inventors: Rongrong Jiang, Jingjun Zhang, Yuqian Dou, Lei Wang, Chuanling Li, Yunhua Chen, Xiaogang Hao, Qiang Lu
  • Patent number: 11510974
    Abstract: The present invention relates to a mutated virus. Said virus can be an influenza virus of human or other animal origin. The present invention also relates to a method for preparing the mutated virus, the method comprising introducing UAG codons into positions upstream of the stop codons per se of one or more genes of a viral genome by reverse genetic techniques. The present invention further relates to uses of the mutated virus, for example, as a live attenuated vaccine, or in replication of controllable and safe virus models, and the like.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: November 29, 2022
    Assignee: PEKING UNIVERSITY
    Inventors: Demin Zhou, Longlong Si, Xueying Zhou, Ziwei Zhang, Huan Xu, Zhenyu Tian, Chuanling Zhang, Sulong Xiao, Qing Xia, Lihe Zhang
  • Publication number: 20200268870
    Abstract: The present invention relates to a mutated virus. Said virus can be an influenza virus of human or other animal origin. The present invention also relates to a method for preparing the mutated virus, the method comprising introducing UAG codons into positions upstream of the stop codons per se of one or more genes of a viral genome by reverse genetic techniques. The present invention further relates to uses of the mutated virus, for example, as a live attenuated vaccine, or in replication of controllable and safe virus models, and the like.
    Type: Application
    Filed: August 2, 2016
    Publication date: August 27, 2020
    Inventors: Demin Zhou, Longlong Si, Xueying Zhou, Ziwei Zhang, Huan Xu, Zhenyu Tian, Chuanling Zhang, Sulong Xiao, Qing Xia, Lihe Zhang
  • Patent number: 10087217
    Abstract: The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses thereof. Specifically, the present invention uses genetic code expansion techniques to incorporate non-natural amino acid into an adeno-associated virus capsid protein VP1 or fragment thereof, thereby obtaining an adeno-associated virus with site-directed mutagenesis using the non-natural amino acid. The adeno-associated virus with site-directed mutagenesis is equivalent to a wild-type virus in terms of production, transduction and mobility, can couple with other functional molecules, such as targeting molecules, and can carry a functional gene in a normal manner, which indicates that the adeno-associated virus with site-directed mutagenesis can be used as a tool adeno-associated virus, and applied in various aspects associated with adeno-associated virus such as finding adeno-associated virus binding proteins or using as target genetic therapy vector.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: October 2, 2018
    Assignee: Peking University
    Inventors: Demin Zhou, Chuanling Zhang, Sulong Xiao, Tianzhuo Yao, Yongxiang Zheng, Fei Yu, Longlong Si, Lihe Zhang
  • Publication number: 20160297855
    Abstract: The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses thereof. Specifically, the present invention uses genetic code expansion techniques to incorporate non-natural amino acid into an adeno-associated virus capsid protein VP1 or fragment thereof, thereby obtaining an adeno-associated virus with site-directed mutagenesis using the non-natural amino acid. The adeno-associated virus with site-directed mutagenesis is equivalent to a wild-type virus in terms of production, transduction and mobility, can couple with other functional molecules, such as targeting molecules, and can carry a functional gene in a normal manner, which indicates that the adeno-associated virus with site-directed mutagenesis can be used as a tool adeno-associated virus, and applied in various aspects associated with adeno-associated virus such as finding adeno-associated virus binding proteins or using as target genetic therapy vector.
    Type: Application
    Filed: October 30, 2014
    Publication date: October 13, 2016
    Applicant: Peking University
    Inventors: Demin Zhou, Chuanling Zhang, Sulong Xiao, Tianzhuo Yao, Yongxiang Zheng, Fei Yu, Longlong Si, Lihe Zhang
  • Patent number: 8101379
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: January 24, 2012
    Assignees: Institute of Radiation Medicine Academy of Military Medical Science, Beijing Sanly Sci-Tech Develop Inc. Ltd.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang
  • Publication number: 20100234291
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Application
    Filed: December 22, 2009
    Publication date: September 16, 2010
    Applicants: INSTITUTE OF RADIATION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PLA, Beijing Sanly Sci-Tech Develop Inc. Ltd.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang
  • Publication number: 20100113345
    Abstract: Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.
    Type: Application
    Filed: December 11, 2007
    Publication date: May 6, 2010
    Applicant: BEIJING SANLY SCI-TECH DEVELOP INC. LTD.
    Inventors: Zuze Wu, Aiping Yu, Chuanling Zhang, Zhongxiong Tang