Patents by Inventor Chuanming Larry Duan

Chuanming Larry Duan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Site-specific conjugation of glycoproteins
    Patent number: 6218160
    Abstract: The present invention describes a site specific conjugation method for glycoproteins wherein a stable dihydrazone bond is formed between the glycoproteins and the glycoproteins retain full activity. Also described is a novel glycoprotein-glycoprotein conjugate of the formula wherein X and Y are glycoproteins modified such that the vicinal hydroxyl groups of the carbohydrate moieties in the glycoproteins have been oxidized to aldehydes which are then reacted with a hydrazide functional group to form a hydrazone bond which is represented in Formula I by “—C═NNH—”.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: April 17, 2001
    Assignee: Roche Diagnostics Corporation
    Inventor: Chuanming Larry Duan