Abstract: The present invention belongs to the technical field of biomedicine, and particularly relates to thiophene-phenothiazine compounds and a synthesis method thereof, as well as application thereof in preparation of phototherapy medicines. The present invention provides thiophene-phenothiazine compounds or pharmaceutically acceptable salts thereof, in the structure of which a thiophene structure is successfully fused to a phenothiazine framework, providing a novel molecular scaffold. The special structure exhibits excellent photodynamic activity, has strong wavelength absorption and good photostability in a near-infrared region, and can efficiently generate ROS under red light, and therefore, the thiophene-phenothiazine compound or the pharmaceutically acceptable salt thereof can be used as a photosensitizer. The thiophene-phenothiazine compounds of the present invention have strong photocytotoxicity and high phototherapeutic indexes, exhibit strong photodynamic anti-tumor activity without obvious side effects.

Abstract: The present invention provides a novel phenothiazine-pyridine compound that is an effective photosensitizer useful for photodynamic therapy. Also provided is a method for inhibiting cell proliferation or for treating a disease involving inappropriate cell proliferation.

Abstract: The present invention provides a novel phenothiazine-pyridine compound that is an effective photosensitizer useful for photodynamic therapy. Also provided is a method for inhibiting cell proliferation or for treating a disease involving inappropriate cell proliferation.