Abstract: A medical device adapted for contact with a vessel or cavity in the body including a tubular portion is provided. The device has an external surface including an external substance that is at least one of a coating or an impregnation, comprising alexidine in an amount that is both anti thrombogenically effective and anti microbially effective. The device also has an internal surface including an internal substance that is at least one of a coating or an impregnation, comprising alexidine in an amount that is both anti thrombogenically effective and anti microbially effective.

Abstract: The invention discloses a method for preparing a flaky iron oxide. The flaky iron oxide is obtained through a vacuum coating machine. The vacuum coating machine includes a vacuum pump, a vacuum pipeline arrangement, a vacuum coating chamber, a flaky iron oxide supporting chamber and an electrical discharging gas inlet. High-energy particles generated by an iron oxide target are deposited on the surface of the conveying belt; and then the flaky iron oxide on a conveying belt is stripped and calcined to obtain the flaky iron oxide with bright color. By means of the method, vacuum sputtering time can be controlled to prepare the flaky iron oxide with various diameter-to-thickness ratios, and pollution caused by a traditional chemical deposition preparation method can be avoided. The preparation method is simple and environment-friendly. Due to the adoption of roller transmission, the production efficiency is improved.

Abstract: A wound care product and related methods of treatment for wound site infection and for healing a wound is disclosed. The wound care product includes alexidine and a substrate and/or a pharmaceutically acceptable carrier.

Abstract: An antimicrobial composition comprising alexidine, a solvent, an optional carrier polymer and one or more excipient or additives is provided. The antimicrobial composition is used to provide antimicrobial properties to a surgical device during surgery and after surgery. The antimicrobial composition is also used to disinfect a surgical device or a surgical site.

Abstract: The invention discloses a method for preparing a flaky iron oxide. The flaky iron oxide is obtained through a vacuum coating machine. The vacuum coating machine includes a vacuum pump, a vacuum pipeline arrangement, a vacuum coating chamber, a flaky iron oxide supporting chamber and an electrical discharging gas inlet. High-energy particles generated by an iron oxide target are deposited on the surface of the conveying belt; and then the flaky iron oxide on a conveying belt is stripped and calcined to obtain the flaky iron oxide with bright color. By means of the method, vacuum sputtering time can be controlled to prepare the flaky iron oxide with various diameter-to-thickness ratios, and pollution caused by a traditional chemical deposition preparation method can be avoided. The preparation method is simple and environment-friendly. Due to the adoption of roller transmission, the production efficiency is improved.

Abstract: An implantable orthopedic device having an antimicrobial coating on at least one surface thereof is disclosed. The antimicrobial coating includes alexidine and a carrier polymer.

Abstract: An antimicrobial composition comprising alexidine, a solvent, an optional carrier polymer and one or more excipient or additives is disclosed. The antimicrobial composition is used to provide antimicrobial properties to a surgical device during surgery and after surgery. The antimicrobial composition is also used to disinfect a surgical device or a surgical site.

Abstract: A wound care product and related methods of treatment for wound site infection and for healing a wound is disclosed. The wound care product includes alexidine and a substrate and/or a pharmaceutically acceptable carrier.

Abstract: A stent has a body and a surface with at least a portion of the surface comprising metal with a coating thereon. The coating is selected from the group consisting of thiols and disulfides and combinations thereof. The thiols are of the form R—SH and the disulfide of the form R—S—S—R″ where R is an alkyl group and R″ is an alkyl group. The metal is selected from the group consisting of noble metals, silver and copper.

Abstract: A stent has a body and a surface with at least a portion of the surface comprising metal with a coating thereon. The coating is selected from the group consisting of thiols and disulfides and combinations thereof. The thiols are of the form R-SH and the disulfide of the form R-S-S-R″ where R is an alkyl group and R″ is an alkyl group. The metal is selected from the group consisting of noble metals, silver and copper.

Abstract: A stent has a body and a surface with at least a portion of the surface comprising metal with a coating thereon. The coating is selected from the group consisting of thiols and disulfides and combinations thereof. The thiols are of the form R—SH and the disulfide of the form R—S—S—R″ where R is an alkyl group and R″ is an alkyl group. The metal is selected from the group consisting of noble metals, silver and copper.