Patents by Inventor Chuanzan Zhao

Chuanzan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9200323
    Abstract: The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: December 1, 2015
    Assignees: CapitalBio Corporation, Tsinghua University
    Inventors: Huafang Gao, Ze Li, Dong Wang, Yanhua Liu, Xiang Liu, Yangzhou Jiang, Li Li, Chuanzan Zhao, Gengxin Lan, Tao Guo, Bin Cai, Jing Cheng
  • Publication number: 20090156419
    Abstract: The present invention provides an improved nucleic acid hybridization process employing a modified oligonucleotide probe comprising naturally occurring nucleotide bases. At least one nucleotide in the modified oligonucleotide is artificially mismatched relative to the control nucleic acid in addition to any mismatches arising from a variant nucleic acid target containing a sequence variation. The artificial mismatch and the sequence variation positions are separated from one another on the oligonucleotide by six to nine nucleotide positions.
    Type: Application
    Filed: February 6, 2007
    Publication date: June 18, 2009
    Inventors: Huafang Gao, Ze Li, Dong Wang, Yanhua Liu, Xiang Liu, Yangzhou Jiang, Li Li, Chuanzan Zhao, Gengxin Lan, Tao Guo, Bin Cai, Jing Cheng
  • Publication number: 20090143245
    Abstract: The present invention provides a microarray for detecting a genotype at a polymorphic site in a plurality of nucleic acid samples, comprising a first set of nucleic acid fragments derived from the samples and a second set of nucleic acid fragments derived from a plurality of references immobilized thereon. The invention also provides a microarray comprising a set of nucleic acid fragments immobilized on the surface of the microarray, wherein the nucleic acid fragments are derived from the samples by amplifying a region in the sample containing the polymorphism through asymmetric PCR amplification. Methods of using and making the microarrays are also provided.
    Type: Application
    Filed: February 20, 2006
    Publication date: June 4, 2009
    Inventors: Huafang Gao, Ze Li, Dong Wang, Yanhua Liu, Xiang Liu, Yangzhou Jiang, Chuanzan Zhao, Li Li, Gengxin Lan, Tao Guo, Bin Cai, Wanli Xing, Yuxiang Zhou, Jing Cheng