Abstract: Disclosed herein are antibodies directed against CRTAM, nucleic acids encoding such antibodies, host cells comprising such nucleic acids encoding the antibody, methods for preparing anti-CRTAM antibodies, and methods for the treatment of diseases, e.g., human cancers, including but not limited to small cell lung cancer, non-small cell lung cancer (including squamous carcinomas and adenocarcinomas) skin cancer including melanoma, breast cancer (including TNBC), colorectal cancer, gastric cancer, ovarian cancer, cervical cancer, prostate cancer, kidney cancer, liver cancer including hepatocellular carcinoma, pancreatic cancer, head and neck cancer, nasopharyngeal cancer, oesophageal cancer, bladder cancer and other uroepithelial cancers, stomach cancer, glioma, glioblastoma, testicular, thyroid, bone, gallbladder and bile ducts, uterine, adrenal cancers, sarcomas, GIST, neuroendocrine tumours, and haematological malignancies.

Abstract: Low capacitance, low threshold voltage annular MOSFET transistors are disclosed. Both low junction capacitance and low threshold voltage are achieved without degradation of drain current due to application of back-bias to the substrate upon which the transistor is formed. A polysilicon annulus, rather than the drain region, abuts field oxide regions, thereby preventing junction capacitance at interface of field oxide and drain (or source). Annular MOSFETs can be fabricated using conventional CMOS processing technology.