Patents by Inventor Chuiwen Qian

Chuiwen Qian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HSP90 inhibitor and preparation method and use thereof
    Patent number: 9630925
    Abstract: Disclosed are an Hsp90 inhibitor and a preparation method and use thereof. The Hsp90 inhibitor is 2-(4-(3-acetylcarnitineacyloxy)cyclohexylamino)-4-(1-(3,6,6-trimethyl-4-oxy-4,5,6,7-tetrahydroindazole))benzamide. The Hsp90 inhibitor has good water solubility and high bioavailability, and can effectively inhibit the proliferation of cancer cells, such as leukemia, cervical cancer, breast cancer, human laryngeal epithelial carcinoma, or malignant melanoma cells. It can also effectively inhibit the activity of herpes simplex virus. The maximal non-toxic concentration of the Hsp90 inhibitor on normal cells is a high, and the Hsp90 inhibitor only has specific inhibition effect on cancer cells.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: April 25, 2017
    Assignee: Jinan University
    Inventors: Yifei Wang, Guowen Xing, Huaiqiang Ju, Wenhui Lin, Chuiwen Qian, Min Xia, Xiaoping Zhou, Meiying Zhang
  • HSP90 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
    Publication number: 20130190509
    Abstract: Disclosed are an Hsp90 inhibitor and a preparation method and use thereof. The Hsp90 inhibitor is 2-(4-(3-acetylcarnitineacyloxy)cyclohexylamino)-4-(1-(3,6,6-trimethyl-4-oxy-4,5,6,7-tetrahydroindazole))benzamide. The Hsp90 inhibitor has good water solubility and high bioavailability, and can effectively inhibit the proliferation of cancer cells, such as leukemia, cervical cancer, breast cancer, human laryngeal epithelial carcinoma, or malignant melanoma cells. It can also effectively inhibit the activity of herpes simplex virus. The maximal non-toxic concentration of the Hsp90 inhibitor on normal cells is a high, and the Hsp90 inhibitor only has specific inhibition effect on cancer cells.
    Type: Application
    Filed: February 16, 2011
    Publication date: July 25, 2013
    Inventors: Yifei Wang, Guowen Xing, Huaiqiang Ju, Wenhui Lin, Chuiwen Qian, Min Xia, Xiaoping Zhou, Meiying Zhang