Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: The present disclosure relates to a novel antibody-drug conjugate (ADC) targeting claudin 18 isoform 2 (CLDN18.2), an active metabolite of the ADC, a method of producing the ADC, use of the ADC for the treatment and/or prevention of diseases, and use of the ADC for producing a drug for the treatment and/or prevention of diseases, more specifically hyperproliferative and/or angiogenic diseases, for example, cancer, and more particularly, to an antibody-drug conjugate including a novel antibody or antigen-binding fragment thereof that binds to CLDN18.2, and a pharmaceutical composition including the same.

Abstract: Provided is a customized exercise system including exercise equipment comprising a sensor, a server storing information about an exercise method and an exercise amount corresponding to a body condition, and a mobile terminal receiving information about an exercise method and an exercise amount that are suitable for a user from the server and providing the transmitted information to the exercise equipment, in which a body condition of an individual user is determined using the sensor.

Abstract: Provided is a customized exercise system including exercise equipment comprising a sensor, a server storing information about an exercise method and an exercise amount corresponding to a body condition, and a mobile terminal receiving information about an exercise method and an exercise amount that are suitable for a user from the server and providing the transmitted information to the exercise equipment, in which a body condition of an individual user is determined using the sensor.

Abstract: A refrigerator which includes a refrigerating compartment and a freezing compartment, a first evaporator and a second evaporator corresponding to the refrigerating compartment and the freezing compartment, respectively, a compressor compressing refrigerant to be supplied to the first and second evaporators, a first fan and a second fan supplying cool air to the compartments, respectively, an external temperature sensor detecting an external temperature of the refrigerator, a multi-directional valve supplying the refrigerant to at least one of the evaporators, and a control unit operating the compressor and the multi-directional valve, and driving the first fan and the second fan until temperatures of the compartments reach a predetermined reference temperature.

Abstract: There is provided an external inline LPG fuel pump, and more particularly, an external inline LPG fuel pump; in which bushings are installed at first and second shafts of a motor to be fixed inside a housing, a ball is completely coupled to an end of the first shaft to prevent the motor from being shaken due to the bushings, and another ball is inserted into an end of the second shaft to fix the motor, thereby preventing the durability of the fuel pump from deteriorating by wear of a bushing part, a pumping part and an inside of the housing even though an LPG fuel is introduced when the motor is driven, prolonging the life of the fuel pump and reducing the repair and exchange costs involved with the fuel pump; in which a case inside which the housing is positioned is formed and a partition is installed inside the case, thereby cooling the high-temperature LPG fuel discharged through an outlet of the housing to reduce heat load and improving the durability of a device receiving the LPG fuel transferred from th

Abstract: The present invention relates to an insulator integrated with a clamp. The insulator integrated with a clamp according to the present invention includes a center rod (10), a connecting cap (20), and a clamp (50). The center rod (10) includes an insulating rod (12) made of a glass material, and an insulating coating (14) made of a polymer material. The connecting cap (20) is connected to a first end of the center rod (10). The clamp (50) includes a body (52) provided with a wedge-shaped casing unit (521) having an inner space and a connecting unit (522) formed on one end of the casing unit, and a pair of jaw elements (54) disposed in the inner space of the casing unit and pushed inward by springs, so that an interval between the jaw elements is reduced to perform a clamping operation.

Abstract: A refrigerator which includes a refrigerating compartment and a freezing compartment, a first evaporator and a second evaporator corresponding to the refrigerating compartment and the freezing compartment, respectively, a compressor compressing refrigerant to be supplied to the first and second evaporators, a first fan and a second fan supplying cool air to the compartments, respectively, an external temperature sensor detecting an external temperature of the refrigerator, a multi-directional valve supplying the refrigerant to at least one of the evaporators, and a control unit operating the compressor and the multi-directional valve, and driving the first fan and the second fan until temperatures of the compartments reach a predetermined reference temperature.

Abstract: Provided are a method and apparatus for providing and using content advisory (CA) information on Internet contents. A method of providing CA information by using a CA information server, includes receiving a request for the CA information on a content, from an Internet Protocol television (IPTV); searching for CA information on the content; and transmitting the found CA information to the IPTV. A method of using CA information when an IPTV reproduces a content not having the CA information, according to the present invention, includes transmitting a request for CA information, to a CA information server; receiving the CA information from the CA information server; analyzing the CA information; and applying the CA information.