Abstract: The present invention relates to radiation cross-linked collagen gel, and a preparation method and usage method thereof. To this end, the present invention comprises a cross-linked collagen material made by irradiating liquid collagen with radioactive rays, wherein the concentration of said collagen is specifically 0.1-10% (W/V), and the radiation dose (dose rate×time) is 0.1-40 kGy on the basis of 1 kGy/hr. The present invention configured as above can prepare a formulated collagen gel using a physical cross-linking method instead of a chemical cross-linking method, specifically carries out the formulation by mixing biocompatible materials, and provides a method capable of using a cross-linked collagen hydrogel in wound dressings, graft materials, cell cultures and the like. Therefore, the present invention provides an industrially convenient and safe preparation method, thereby instilling a good image to a customer by greatly improving the quality and confidence in the products.

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract: Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.

Abstract: A method and system for providing video-on-demand services are provided. The method of providing video-on-demand (VOD) services comprises transmitting service information to a set-top box via an out-of-band channel, receiving location and identification information of the set top box via the out-of-band channel, receiving a VOD service request from the set-top box via the out-of-band channel, and providing the set-top box with the requested content via an in-band channel with reference to the location and identification information of the set-top box.

Abstract: The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.

Abstract: The present invention relates to a composition for cartilaginous tissue repair and to a production method therefor. The present invention comprises the steps of: (a) dissolving freeze-dried fibrinogen in an aprotinin solution; (b) dissolving freeze-dried thrombin in a stabilizing solution; (c) mixing an enriched collagen solution with thrombin and the stabilizing solution; and installing the fibrinogen solution (a) to one side of a dual kit and the solution (c) containing the collagen to the other side, and then mixing and injecting into damaged cartilaginous tissue. In the present invention, which is constituted as described above, biomaterials such as collagen and fibrin are mixed so as to allow damaged cartilaginous tissue to be repaired to a state allowing transplantation onto the tissue, and efficient regeneration is induced, thereby making it possible to reduce surgery-related stress on people and animals while inducing relatively rapid and efficient cartilage repair and regeneration.

Abstract: Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Abstract: Disclosed herein is a method for preparing a collagen gel composition for bone regeneration comprising collecting bone marrow from animal tissues and isolating nucleated cells from the bone marrow; and mixing the nucleated cells and a bio-matrix composed of type I collagen and apatite.

Abstract: Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Abstract: A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.

Abstract: A method of manufacturing a cell using a pouch of aluminum multilayered film is disclosed. The pouch of an aluminum multilayered film is used as the outer case of the cell. The method includes: inserting an electrode assembly, which is composed of a negative electrode, separator, and positive electrode, in the pouch; sealing the electrode assembly; and bending the sealed portion of the cell once or twice. Therefore, the present invention can enhance the safety and energy density of the cell.

Abstract: The present invention relates to a method of making a polymeric porous separation membrane for a lithium ion polymer battery, the method comprising: providing a porous polyolefin membrane and a polymer solution of the concentration of 1–20 weight % in an organic solvent fabricated by dissolving in an organic solvent a polymer compound that is stable in an electrolyte containing a lithium salt and can be gelled in the electrolyte, at the temperature of 10–40° C.; and fabricating a polymeric porous separation membrane by coating the polymeric porous polyolefin membrane with the polymer solution. Thus, the porous separation membrane for a lithium ion polymer battery is fabricated by using the polymer solution fabricated at the low temperatures of 10–40° C., and the size of the pores of the coated is proper, so that the containing capacity of the electrolyte and the ion conductivity are good. Further gelling at low pressure is enabled and cohesive force to the electrodes is improved.

Abstract: A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated collagen is salt-treated for fractionation and ethanol-treated for obtaining 5˜10% of collagen from the initial tissue weight. The prepared tissues are processed for separating collagen through the collagen separating process. The separated collagen is processed for preparing product. The method for preparing product is comprised: treating a collagen solution having a predetermined concentration under a neutral condition at a low temperature, followed by overnight treatment at a temperature of 30 to 35° C.

Abstract: The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: wherein one of is a double bond, as valency permits; and R2, R4, X1A, X2A, X1B, X2B, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.

Abstract: A method and system for providing video-on-demand services are provided. The method of providing video-on-demand (VOD) services comprises transmitting service information to a set-top box via an out-of-band channel, receiving location and identification information of the set top box via the out-of-band channel, receiving a VOD service request from the set-top box via the out-of-band channel, and providing the set-top box with the requested content via an in-band channel with reference to the location and identification information of the set-top box.

Abstract: The present invention provides a method and apparatus enabling multiple CPU systems to independently access a shared device, each of the multiple CPU systems having data I/O lines, a reset line, a clock line and the like without requiring an additional switching logic or circuit. The method of sharing the device among multiple CPU systems according to an embodiment of the present invention comprises setting interfaces of all the systems to a floating state, determining the status of a PIO indicating whether it is possible to access the device, and the status of the PIO to an access-disable state. The method of sharing the device among multiple CPU systems further comprises changing the status of an interface of a first system, which intends to access the device, so that communications can be made between the first system and the device, and transmitting and receiving data between the first system and the device.

Abstract: The present invention relates to a method of making a polymeric porous separation membrane for a lithium ion polymer battery, the method comprising: providing a porous polyolefin membrane and a polymer solution of the concentration of 1-20 weight % in an organic solvent fabricated by dissolving in an organic solvent a polymer compound that is stable in an electrolyte containing a lithium salt and can be gelled in the electrolyte, at the temperature of 10-40° C.; and fabricating a polymeric porous separation membrane by coating the polymeric porous polyolefin membrane with the polymer solution. Thus, the porous separation membrane for a lithium ion polymer battery is fabricated by using the polymer solution fabricated at the low temperatures of 10-40° C., and the size of the pores of the coated is proper, so that the containing capacity of the electrolyte and the ion conductivity are good. Further gelling at low pressure is enabled and cohesive force to the electrodes is improved.