Patents by Inventor Chulhee Choi

Chulhee Choi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11936502
    Abstract: Disclosed is a method for estimating a channel of a terminal by a base station in a wireless communication system supporting multiple antennas, the method comprising the steps of: estimating a moving speed of the terminal on the basis of a first channel value acquired at a current time point and a second channel value acquired at a previous time point; determining, on the basis of the estimated moving speed, a complexity degree corresponding to the number of channel values for multiple time points including the current time point; and estimating a channel of the terminal at a next time point on the basis of the determined complexity degree.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 19, 2024
    Assignees: Samsung Electronics Co., Ltd., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yongyun Choi, Hwanjin Kim, Chulhee Jang, Junil Choi
  • Publication number: 20240075100
    Abstract: The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 7, 2024
    Applicant: ILIAS BIOLOGICS INC.
    Inventors: Chulhee Choi, Nambin Yim, Won Do Heo, Seung-Wook Ryu, Hojun Choi, Kyungsun Choi
  • Patent number: 11872193
    Abstract: The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: January 16, 2024
    Assignee: ILIAS BIOLOGICS INC.
    Inventors: Chulhee Choi, Nambin Yim, Won Do Heo, Seung-Wook Ryu, Hojun Choi, Kyungsun Choi
  • Patent number: 11696939
    Abstract: The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-?B) inhibitor and a photo-specific binding protein.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: July 11, 2023
    Assignees: ILIAS Biologics Inc., ILIAS Therapeutics, Inc.
    Inventors: Chulhee Choi, Kyungsun Choi, Ramkumar Menon
  • Publication number: 20210299215
    Abstract: The present disclosure relates to methods for treating acute kidney injury using exosome containing NF-?B inhibitors. The present disclosure relates to methods for treating diseases induced by sepsis using exosome containing NF-?B inhibitor. The present disclosure also is related to methods for treating respiratory diseases, such as viral respiratory diseases, using exosome containing NF-?B inhibitor.
    Type: Application
    Filed: April 11, 2021
    Publication date: September 30, 2021
    Applicant: Ilias Biologics Inc.
    Inventors: Chulhee Choi, Kyungsun Choi, Jae-Kwang Yoo
  • Publication number: 20210275636
    Abstract: The present invention is related to compositions containing extracellular vesicles (exosomes) and methods of using the same for increasing lifespan of fetus, viability of fetus, or viability of newborn, for treating inflammation in uterus and/or fetus, for delaying preterm birth, or for treating a condition related to inflammation in uterus and/or fetus, wherein the extracellular vesicles comprising a nuclear factor kappa beta (NF-?B) inhibitor and a photo-specific binding protein.
    Type: Application
    Filed: December 30, 2020
    Publication date: September 9, 2021
    Inventors: Chulhee CHOI, Kyungsun CHOI, Ramkumar MENON
  • Publication number: 20200289614
    Abstract: The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Applicant: ILIAS BIOLOGICS INC.
    Inventors: Chulhee CHOI, Nambin YIM, Won Do HEO, Seung-Wook RYU, Hojun CHOI, Kyungsun CHOI
  • Patent number: 10702581
    Abstract: The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: July 7, 2020
    Assignee: ILIAS BIOLOGICS INC.
    Inventors: Chulhee Choi, Nambin Yim, Won Do Heo, Seung-Wook Ryu, Hojun Choi, Kyungsun Choi
  • Publication number: 20200206360
    Abstract: The present invention provides a method for producing an exosome that transfers an active substance specifically to a target and the exosome produced by the same; a method for delivering the active substance to the target tissue using the exosome; a pharmaceutical composition for delivery of the active substance comprising the exosome as an active ingredient; and a composition for preparing the exosome comprising an expression vector wherein the target peptide is inserted into an extracellular portion of a transmembrane protein.
    Type: Application
    Filed: August 16, 2018
    Publication date: July 2, 2020
    Applicants: ILIAS BIOLOGICS INC., ILIAS THERAPEUTICS, INC.
    Inventors: Chulhee CHOI, Nambin YIM, Hojun CHOI, Kyungsun CHOI, Seung-Wook RYU
  • Patent number: 10015032
    Abstract: A method of acquiring frequency hop timing synchronization includes a propagation delay time computation process of computing a minimum and maximum propagation delay times according to an error of a location of a satellite communication terminal, which is input by an operator of a ground satellite terminal, and a delay transmission process of transmitting a ranging signal after a certain time upon the transmission of the ranging signal through a ranging-dedicated hop group having a hop duration time that is set in consideration of the maximum propagation delay, the minimum propagation delay, a ranging time, and a timing error due to a positional change of a satellite, in order to avoid collisions between the ranging signal and other signals. The satellite communication terminal may receive a ranging signal that was transmitted by the satellite communication terminal and control a timing for determining whether synchronization is acquired and a timing for performing transmission.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: July 3, 2018
    Assignee: AGENCY FOR DEFENSE DEVELOPMENT
    Inventors: Juhyung Lee, Byunggak Jo, Chulhee Choi, Dhongwoon Jang, Yeesoo Han
  • Publication number: 20180117117
    Abstract: The present invention relates to a method for the mass-production of exosome comprising a cargo protein, a vector for preparing the exosome, exosome including a cargo protein prepared by the method, and a method for loading the cargo protein to cytosol by using the exosome prepared thereby. According to the method for preparing an exosome comprising a cargo protein provided by the present invention, the exosome loaded with a cargo protein can be produced with a high yield, so that it can be used broadly in the treatment of disease using the exosome.
    Type: Application
    Filed: November 3, 2017
    Publication date: May 3, 2018
    Applicant: CELLEX LIFE SCIENCES, INCORPORATED
    Inventors: Chulhee CHOI, Nambin YIM, Won Do HEO, Seung-Wook RYU, Hojun CHOI, Kyungsun CHOI
  • Publication number: 20170141939
    Abstract: A method of acquiring frequency hop timing synchronization includes a propagation delay time computation process of computing a minimum and maximum propagation delay times according to an error of a location of a satellite communication terminal, which is input by an operator of a ground satellite terminal, and a delay transmission process of transmitting a ranging signal after a certain time upon the transmission of the ranging signal through a ranging-dedicated hop group having a hop duration time that is set in consideration of the maximum propagation delay, the minimum propagation delay, a ranging time, and a timing error due to a positional change of a satellite, in order to avoid collisions between the ranging signal and other signals. The satellite communication terminal may receive a ranging signal that was transmitted by the satellite communication terminal and control a timing for determining whether synchronization is acquired and a timing for performing transmission.
    Type: Application
    Filed: October 26, 2016
    Publication date: May 18, 2017
    Applicant: AGENCY FOR DEFENSE DEVELOPMENT
    Inventors: Juhyung LEE, Byunggak JO, Chulhee CHOI, Dhongwoon JANG, Yeesoo HAN
  • Patent number: 9393308
    Abstract: Disclosed herein are a nanopreparation having a micelle structure for diagnosis or treatment of cancer diseases, and a method of preparing the same, and more particularly, a nanopreparation having a micelle structure available for diagonosis or treatment of cancer diseases and a method for preparing the same, wherein the nanopreparation is prepared by encapsulating a photosensitizer by forming micelle with polymeric lipid DSPE-mPEG. The nanopreparation having the micelle structure according to the present invention has a size of 12 nm or less by encapsulating hypericin, which is a photosensitizer, by forming micelle with polymeric lipid DSPE-mPEG having a molecular weight of 1500 to 2500. Resultingly, the nanopreparation easily overcomes a blood-tumor barrier (BTB) and an interstitial fluid pressure and has light induced cytotoxicity efficiency that is about more than 2.5 times higher than that of the case where hypericin is used alone.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: July 19, 2016
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Chulhee Choi, Kyuha Chong, Jiho Park
  • Publication number: 20150148428
    Abstract: Disclosed herein are a nanopreparation having a micelle structure for diagnosis or treatment of cancer diseases, and a method of preparing the same, and more particularly, a nanopreparation having a micelle structure available for diagonosis or treatment of cancer diseases and a method for preparing the same, wherein the nanopreparation is prepared by encapsulating a photosensitizer by forming micelle with polymeric lipid DSPE-mPEG. The nanopreparation having the micelle structure according to the present invention has a size of 12 nm or less by encapsulating hypericin, which is a photosensitizer, by forming micelle with polymeric lipid DSPE-mPEG having a molecular weight of 1500 to 2500. Resultingly, the nanopreparation easily overcomes a blood-tumor barrier (BTB) and an interstitial fluid pressure and has light induced cytotoxicity efficiency that is about more than 2.5 times higher than that of the case where hypericin is used alone.
    Type: Application
    Filed: June 26, 2014
    Publication date: May 28, 2015
    Inventors: Chulhee Choi, Kyuha Chong, Jiho Park
  • Patent number: 8483819
    Abstract: Disclosed herein is a modulator of vascular permeability using pulsed laser and a method for modulating vascular permeability using the same. More specifically, because the pulsed laser effectively induces vascular permeabilization, effectively delivers intravascular materials into tissues and minimizes insult to the tissues by the induced vascular permeabilization, and locally targets a subcutaneous tissue for noninvasive modulation due to its nonlinearity, it may be usefully used for modulation of permeability.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: July 9, 2013
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Chulhee Choi, Myunghwan Choi
  • Patent number: 8285353
    Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: October 9, 2012
    Assignee: Korea Advanced Institute of Science and Technology
    Inventors: Chulhee Choi, Yujung Kang, Myunghwan Choi
  • Publication number: 20110152744
    Abstract: Disclosed herein is a modulator of vascular permeability using pulsed laser and a method for modulating vascular permeability using the same. More specifically, because the pulsed laser effectively induces vascular permeabilization, effectively delivers intravascular materials into tissues and minimizes insult to the tissues by the induced vascular permeabilization, and locally targets a subcutaneous tissue for noninvasive modulation due to its nonlinearity, it may be usefully used for modulation of permeability.
    Type: Application
    Filed: May 21, 2010
    Publication date: June 23, 2011
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Chulhee CHOI, Myunghwan CHOI
  • Publication number: 20100036217
    Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.
    Type: Application
    Filed: July 11, 2007
    Publication date: February 11, 2010
    Applicant: Korea Advanced Institute Of Science and Technology
    Inventors: Chulhee Choi, Yujung Kang, Myunghwan Choi
  • Publication number: 20080221421
    Abstract: The present invention relates to an apparatus for measuring the perfusion rate of legs. The measurement apparatus of the present invention includes a light leakage prevention unit including a light emitting device for radiating light having a certain wavelength onto a living body injected with Indocyanine Green (ICG), and a light leakage prevention housing formed to prevent transmission of external light. A data acquisition unit includes a band pass filter for passing therethrough only light, having a near infrared wavelength, in a fluorescence image emitted by the ICG and the light emitting device, and a Charge Coupled Device (CCD) camera for photographing a near infrared wavelength region. A data processing unit calculates a perfusion rate of the living body on a basis of data about the near infrared wavelength region through a data cable connected to the data acquisition unit. A data output unit outputs the perfusion rate calculated by the data processing unit.
    Type: Application
    Filed: December 13, 2007
    Publication date: September 11, 2008
    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Chulhee CHOI, Yujung KANG, Myunghwan CHOI