Abstract: A tomographic imaging system includes a light source, a light irradiation unit that irradiates light to a transparent material composite thin film sample and a reference mirror and acquires an interference signal between light reflected and scattered from the sample and light reflected from the reference mirror, a light measuring unit that measures the interference signal acquired by the light irradiation unit, a light transmission unit that transmits the light output from the light source to the light irradiation unit and transmits the interference signal of the light transmitted from the light irradiation unit to the light measuring unit; and a signal processing apparatus that converts the interference signal of the sample, outputs the converted interference signal as a tomographic image, and monitors the interference signal acquired by the light irradiation unit to modulate intensity and a polarization state of the light input to the light irradiation unit.

Abstract: A tomographic imaging system includes a light source, a light irradiation unit that irradiates light to a transparent material composite thin film sample and a reference mirror and acquires an interference signal between light reflected and scattered from the sample and light reflected from the reference mirror, a light measuring unit that measures the interference signal acquired by the light irradiation unit, a light transmission unit that transmits the light output from the light source to the light irradiation unit and transmits the interference signal of the light transmitted from the light irradiation unit to the light measuring unit; and a signal processing apparatus that converts the interference signal of the sample, outputs the converted interference signal as a tomographic image, and monitors the interference signal acquired by the light irradiation unit to modulate intensity and a polarization state of the light input to the light irradiation unit.

Abstract: A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Abstract: A method and an apparatus for diagnosing a brain tumor in real-time are disclosed. A method for detecting a brain tumor in real-time can comprise the steps of: generating, by a probe, a plurality of input signals and transferring the same to a target detection region which is estimated to be the location of a brain tumor; receiving, by the probe, a plurality of reflection signals on the basis of a plurality of input signals; and detecting, by the probe, a plurality of the received reflection signals, wherein a plurality of the input signals comprise a terahertz signal, an optical coherence tomography (OCT) signal, and a Raman signal, and a plurality of the reflection signals can be used for generating a plurality of image information for detecting the location of a brain tumor; and an apparatus for diagnosing a brain tumor in vitro and in real-time, can be used to diagnose, in real-time, a brain tumor specimen, which is extracted from the brain.

Abstract: The present invention relates to an optical head for revealing near field through beams irradiated from a light source of a far field optical system, the optical head including: a flexible substrate made of a soft material and adapted to allow the optical head to be brought into close contact with a measured object and attached thereto even if the measured object has a curved or flat surface; and a near-field revelation part located between the measured object and the flexible substrate in such a manner as to have one side brought into contact with the flexible substrate and the other side detachably attached to the measured object and adapted to reveal the near field through the beams irradiated from the light source.

Abstract: The present invention relates to an apparatus for measuring concentration of hemoglobin in blood using a photothermal effect, the apparatus including: a reference light source unit for radiating a reference beam; a photothermal light source unit for radiating a photothermal beam from which the photothermal effect is generated; a cuvette unit for accommodating a collected blood sample thereinto and having first and second reflection layers; and a concentration operation unit for calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source unit onto the first and second reflection layers of the cuvette unit as the photothermal beam radiated from the photothermal light source unit is incident onto the cuvette unit and absorbed by hemoglobin to generate the photothermal effect through the emission of heat.

Abstract: A cardiovascular OCT image making method which reduces artifacts includes the steps of: inputting a cardiovascular OCT image; converting coordinates of the inputted OCT image into two-dimensional polar coordinates (? and r); generating a brightness control function of the A-line direction based on the blood wall relative to each ? value; forming a brightness image in the A-line direction based on the blood wall depending on the brightness control function; and forming an OCT image of which brightness is controlled by the brightness image by applying the brightness image formed on the inputted OCT image.

Abstract: An apparatus for measuring a hemoglobin concentration includes a reference light source unit, a light and heat light source unit configured to emit a light and heat beam for generating a light and heat effect, an accommodation unit configured to accommodate obtained blood samples, an image acquisition unit configured to write a primary pattern formed after the reference beam emitted by the reference light source unit is incident on the accommodation unit and a secondary pattern formed under an influence of a light and heat effect after the light and heat beam emitted by the light and heat light source unit is incident on the accommodation unit, and a concentration calculation unit electrically connected to the image acquisition unit and configured to calculate a hemoglobin concentration based on a difference between the primary pattern and the secondary pattern.

Abstract: The present invention relates to a high-throughput label-free cell assay system which scans a lower part of medium made of glass using an object lens and a Galvano mirror and using a broadband laser as a light source, analyzes and visualizes light reflected from the lower part of the medium using a spectrometer, measures interference spectra formed by the light reflected from each interface of the medium using the spectrometer, and measures phase from data that the measured interference spectra were converted by Fourier transform to observe structural change of cells. The system includes a transparent medium on which a sample is put, an object lens located beneath the transparent medium; a Galvano mirror located beneath the object lens; an optical fiber coupler transferring light from the super-continuum light source to the Galvano mirror; and the spectrometer detecting spectrum of the light from the optical fiber coupler.

Abstract: An apparatus for measuring a hemoglobin concentration includes a reference light source unit, a light and heat light source unit configured to emit a light and heat beam for generating a light and heat effect, an accommodation unit configured to accommodate obtained blood samples, an image acquisition unit configured to write a primary pattern formed after the reference beam emitted by the reference light source unit is incident on the accommodation unit and a secondary pattern formed under an influence of a light and heat effect after the light and heat beam emitted by the light and heat light source unit is incident on the accommodation unit, and a concentration calculation unit electrically connected to the image acquisition unit and configured to calculate a hemoglobin concentration based on a difference between the primary pattern and the secondary pattern.

Abstract: A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

Abstract: The present invention relates to an optical head for revealing near field through beams irradiated from a light source of a far field optical system, the optical head including: a flexible substrate made of a soft material and adapted to allow the optical head to be brought into close contact with a measured object and attached thereto even if the measured object has a curved or flat surface; and a near-field revelation part located between the measured object and the flexible substrate in such a manner as to have one side brought into contact with the flexible substrate and the other side detachably attached to the measured object and adapted to reveal the near field through the beams irradiated from the light source.

Abstract: A cardiovascular OCT image making method which reduces artifacts includes the steps of: inputting a cardiovascular OCT image; converting coordinates of the inputted OCT image into two-dimensional polar coordinates (? and r); generating a brightness control function of the A-line direction based on the blood wall relative to each ? value; forming a brightness image in the A-line direction based on the blood wall depending on the brightness control function; and forming an OCT image of which brightness is controlled by the brightness image by applying the brightness image formed on the inputted OCT image.

Abstract: The present invention relates to an apparatus for measuring concentration of hemoglobin in blood using a photothermal effect, the apparatus including: a reference light source unit for radiating a reference beam; a photothermal light source unit for radiating a photothermal beam from which the photothermal effect is generated; a cuvette unit for accommodating a collected blood sample thereinto and having first and second reflection layers; and a concentration operation unit for calculating the concentration of hemoglobin by using the phase changes of interference signals generated from the incidence of the reference beam radiated from the reference light source unit onto the first and second reflection layers of the cuvette unit as the photothermal beam radiated from the photothermal light source unit is incident onto the cuvette unit and absorbed by hemoglobin to generate the photothermal effect through the emission of heat.

Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Abstract: A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

Abstract: A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 104 W/cm2.

Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Abstract: A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.