Abstract: A compiler method converts an indirect call to a callee routine in a caller routine program listing, to an in-line listing of, or a direct call to, the callee routine in the caller routine. An indirect call is a call to a callee routine wherein the callee routine is not absolutely identified until run time of the program listing. The method includes the steps of: comparing plural prospective callee routines in the program listing with characteristics of an indirect caller site in the caller routine and eliminating prospective callee routines which evidence other than a match with those characteristics; employing call statistics associated with remaining prospective callee routines (and the caller routine) to eliminate further ones of the prospective callee routines to arrive at a set of one or more chosen prospective callee routines. The method concludes by in-lining at the indirect caller site at least one of the set of chosen prospective callee routines. As an alternative, a direct call can be inserted.