Abstract: The disclosure provides a method of active immunotherapy for a cancer patient, comprising administering vaccines against Globo series antigens (i.e., Globo H, SSEA-3 and SSEA-4). Specifically, the method comprises administering Globo H-CRM197 (OBI-833/821) in patients with cancer. The disclosure also provides a method of selecting a cancer patient who is suitable as treatment candidate for immunotherapy. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: A switch device includes a P-type substrate, a first gate structure, a first N-well, a shallow trench isolation structure, a first P-well, a second gate structure, a first N-type doped region, a second P-well, and a second N-type doped region. The first N-well is formed in the P-type substrate and partly under the first gate structure. The shallow trench isolation structure is formed in the first N-well and under the first gate structure. The first P-well is formed in the P-type substrate and under the first gate structure. The first N-type doped region is formed in the P-type substrate and between the first gate structure and the second gate structure. The second P-well is formed in the P-type substrate and under the second gate structure. The second N-type doped region is formed in the second P-well and partly under the second gate structure.

Abstract: An audio processing device includes a signal processing circuit, a power switch circuit, a power amplifier and a detection circuit. The signal processing circuit is configured to process an audio input to generate an audio signal. The power switch circuit is configured to generate an operating voltage. The power amplifier is coupled with the signal processing circuit and the power switch circuit, and configured to drive a load circuit by the operating voltage according to the audio signal. The detection circuit is coupled with the signal processing circuit and the power switch circuit, configured to obtain a volume value from the audio signal and compare the volume value with a first volume threshold to generate a comparison result, and configured to control, according to the comparison result, the power switch circuit to set the operating voltage to have a corresponding one of multiple voltage levels.

Abstract: The present invention provides an offset calibration circuit used in a signal processing circuit, wherein the offset calibration circuit includes a supply voltage detection circuit and a calibration circuit. The supply voltage detection circuit is configured to detect a level of a supply voltage to generate a detection result, wherein the supply voltage is provided to an output stage in the signal processing circuit. The calibration circuit is configured to calculate a digital compensation value according to the detection result, wherein the digital compensation value is used for a digital processing circuit in the signal processing circuit to perform a DC offset calibration.

Abstract: An audio processing device includes a signal processing circuit, a power switch circuit, a power amplifier and a detection circuit. The signal processing circuit is configured to process an audio input to generate an audio signal. The power switch circuit is configured to generate an operating voltage. The power amplifier is coupled with the signal processing circuit and the power switch circuit, and configured to drive a load circuit by the operating voltage according to the audio signal. The detection circuit is coupled with the signal processing circuit and the power switch circuit, configured to obtain a volume value from the audio signal and compare the volume value with a first volume threshold to generate a comparison result, and configured to control, according to the comparison result, the power switch circuit to set the operating voltage to have a corresponding one of multiple voltage levels.

Abstract: The present invention provides an offset calibration circuit used in a signal processing circuit, wherein the offset calibration circuit includes a supply voltage detection circuit and a calibration circuit. The supply voltage detection circuit is configured to detect a level of a supply voltage to generate a detection result, wherein the supply voltage is provided to an output stage in the signal processing circuit. The calibration circuit is configured to calculate a digital compensation value according to the detection result, wherein the digital compensation value is used for a digital processing circuit in the signal processing circuit to perform a DC offset calibration.

Abstract: A transmitter circuit is provided in the present disclosure. The transmitter circuit includes a first capacitance, a first current pump circuit for charging or discharging the first capacitance to output a first voltage, a second capacitance, and a second current pump circuit for charging or discharging the second capacitance to output a second voltage. A charging rate at which the first current pump circuit charges the first capacitance or a discharging rate at which the first current pump circuit discharges the first capacitance determines a rising slew rate or a falling slew rate of the first voltage. A charging rate at which the second current pump circuit charges the second capacitance or a discharging rate at which the second current pump circuit discharges the second capacitance determines a rising slew rate or a falling slew rate of the second voltage.

Abstract: A transmitter circuit is provided in the present disclosure. The transmitter circuit includes a first capacitance, a first current pump circuit for charging or discharging the first capacitance to output a first voltage, a second capacitance, and a second current pump circuit for charging or discharging the second capacitance to output a second voltage. A charging rate at which the first current pump circuit charges the first capacitance or a discharging rate at which the first current pump circuit discharges the first capacitance determines a rising slew rate or a falling slew rate of the first voltage. A charging rate at which the second current pump circuit charges the second capacitance or a discharging rate at which the second current pump circuit discharges the second capacitance determines a rising slew rate or a falling slew rate of the second voltage.

Abstract: An auxiliary channel transceiving circuit includes: a first node and a second node; a first voltage-dividing circuit for generating a first received signal according to a signal from the first node; a second voltage-dividing circuit for generating a second received signal according to a signal from the second node; a first receiver amplifying circuit for amplifying the first received signal to generate a first amplified signal; a second receiver amplifying circuit for amplifying the second received signal to generate a second amplified signal; a comparison circuit for comparing the first amplified signal with the second amplified signal to generate a received signal; a first transmitter amplifying circuit for generating a first output signal according to a transmitting signal; and a second transmitter amplifying circuit for generating a second output signal according to the transmitting signal. The auxiliary channel transceiving circuit is not required to cooperate with traditional capacitors.

Abstract: An auxiliary channel transceiving circuit includes: a first node and a second node; a first voltage-dividing circuit for generating a first received signal according to a signal from the first node; a second voltage-dividing circuit for generating a second received signal according to a signal from the second node; a first receiver amplifying circuit for amplifying the first received signal to generate a first amplified signal; a second receiver amplifying circuit for amplifying the second received signal to generate a second amplified signal; a comparison circuit for comparing the first amplified signal with the second amplified signal to generate a received signal; a first transmitter amplifying circuit for generating a first output signal according to a transmitting signal; and a second transmitter amplifying circuit for generating a second output signal according to the transmitting signal. The auxiliary channel transceiving circuit is not required to cooperate with traditional capacitors.